EVIDENCE THAT SPONTANEOUS MITOTIC RECOMBINATION OCCURS AT 2-STRAND STAGE
EVIDENCE THAT SPONTANEOUS MITOTIC RECOMBINATION OCCURS AT 2-STRAND STAGE
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DOI：
10.1073/pnas.75.9.4436
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发表时间：
1978-01-01
影响因子：
11.1
通讯作者：
ESPOSITO, MS
中科院分区：
文献类型：
--
作者：
ESPOSITO, MS
在酵母菌中，自发的互惠有丝分裂重组与异等位基因重组相关，几乎只发生在2链阶段，涉及无复制染色体的重组（即，在有丝分裂的S期）或染色体的无复制区域。相关的异等位基因重组经常反映对称Holliday结构的形成，在异等位基因trp5位点的转换中不存在强烈的极化，偶尔会导致相隔较远的遗传标记同时转换，并且与侧翼标记的重组呈正相关。
Spontaneous reciprocal mitotic recombination in the yeast Saccharomyces cerevisiae, associated with heteroallelic recombination, occurs almost exlusively at the 2-strand stage and involves recombination of unduplicated chromosomes (i.e., during GI) or the unduplicated regions of chromosomes during the S phase of mitosis. The associated heteroallelic recombination frequently reflects the formation of symmetric Holliday structures, is not strongly polarized with respect to conversion at the heteroallelic trp5 sites studies, occasionally results in simultaneous conversion of widely separated genetic markers, and is positively correlated with recombination of flanking markers.