Elevated CSF histamine levels in multiple sclerosis patients.
Elevated CSF histamine levels in multiple sclerosis patients.
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DOI：
10.1186/2045-8118-10-19
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发表时间：
2013
影响因子：
7.3
通讯作者：
Urade Y
中科院分区：
文献类型：
--
作者：
Kallweit U;Aritake K;Bassetti CL;Blumenthal S;Hayaishi O;Linnebank M;Baumann CR;Urade Y
组胺是许多生理过程中普遍存在的炎症介质。组胺及其受体与多发性硬化症（MS）的发病机制有关。我们前瞻性招募了36名MS患者和19名年龄和性别匹配的健康志愿者进行脑脊液（CSF）组胺分析。MS患者样品中的CSF组胺水平（中值：35.6pg/ml）显著高于对照（中值：5.5pg/ml; β = 0.525，p < 0.001）。此外，组胺随年龄增长而增加（Pearson相关性，p < 0.003）。组胺可能是中枢神经系统慢性炎症性疾病发生和维持的重要因素。我们的观察鼓励更深入地研究组胺在MS中的作用。
Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospinal fluid (CSF) histamine analysis. CSF histamine levels in MS patient samples were significantly higher (median: 35.6 pg/ml) than in controls (median: 5.5 pg/ml; Beta = 0.525, p < 0.001). In addition, histamine increased with age (Pearson’s correlation, p < 0.003). Histamine may be an important factor for both the initiation and maintenance of chronic inflammatory diseases of the central nervous system. Our observation encourages a deeper investigation of the role of histamine in MS.