Treatment of dystonia
Treatment of dystonia
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DOI：
10.1016/s1353-8020(08)70031-2
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发表时间：
2007-01-01
影响因子：
4.1
通讯作者：
Jankovic, Joseph
中科院分区：
文献类型：
--
作者：
Adam, Octavian R.;Jankovic, Joseph
肌张力障碍的严重程度从单纯局灶性肌张力障碍（如writer's痉挛）到危及生命的肌张力障碍不等。尽管病理生理学仍然难以捉摸，对症治疗可能提供明显的缓解。肉毒杆菌毒素被认为是大多数局灶性和节段性肌张力障碍的治疗选择。基底节区深部脑刺激，特别是苍白球内刺激，正在成为治疗顽固性、全身性和节段性肌张力障碍的重要方法。基因疗法也正在被探索作为一种可能的治疗遗传性肌张力障碍。本文综述了各种类型肌张力障碍的治疗方法。(c) 2007 Elsevier B.V.版权所有
Dystonia varies in severity from simple focal dystonia, such as writer's cramp to life-threatening status dystonicus. Even though the pathophysiology is still elusive, symptomatic treatments may provide marked relief. Botulinum toxin is considered the treatment of choice for most focal and segmental dystonias. Deep brain stimulation of the basal ganglia, particularly the globus pallidus internum, is emerging as an important treatment for refractory, generalized, and segmental forms of dystonia. Gene therapy is also being explored as a possible treatment of inherited dystonias. This article reviews the therapeutic options available for the various types of dystonia. (c) 2007 Elsevier B.V. All rights reserved.