Principles for designing fluorescent sensors and reporters
Principles for designing fluorescent sensors and reporters
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DOI：
10.1038/nchembio.620
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发表时间：
2011-08-01
影响因子：
14.8
通讯作者：
Schultz, Carsten
中科院分区：
文献类型：
--
作者：
Lemke, Edward A.;Schultz, Carsten
传感器和报告器是细胞生物学中最令人兴奋的工具之一。现在，它们越来越多地用于发育生物学和医学，因为它们使我们能够以真实的时间和高空间分辨率监视活细胞和生物体（包括人类）中的事件。在这里，我们讨论了荧光传感器和报告的多种设计方案，以及改善其性能和增加开发的策略。
Sensors and reporters are among the most exciting tools used in cell biology. Now, they are increasingly used in developmental biology and medicine because they allow us to spy on events in living cells and organisms, including humans, in real time and with high spatial resolution. Herein, we discuss multiple design options for fluorescent sensors and reporters as well as strategies to improve their properties and increase development.