EVIDENCE FOR THE PARTICIPATION OF β1‐ADRENOCEPTORS IN ISOPRENALINE‐INDUCED RENIN RELEASE FROM RAT KIDNEY SLICES in vitro
EVIDENCE FOR THE PARTICIPATION OF β1‐ADRENOCEPTORS IN ISOPRENALINE‐INDUCED RENIN RELEASE FROM RAT KIDNEY SLICES in vitro
复制标题
β1-肾上腺素能受体参与异丙肾上腺素诱导大鼠肾切片体外肾素释放的证据
DOI：
10.1111/j.1476-5381.1978.tb07793.x
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发表时间：
1978
影响因子：
7.3
通讯作者：
J. Schwartz
中科院分区：
文献类型：
--
作者：
E. Desaulles;F. Miesch;J. Schwartz
1观察了4种β-肾上腺素受体拮抗剂对异丙肾上腺素（0.5 mmol/l）诱导的大鼠肾片肾素释放的抑制作用。此外，在豚鼠离体心房和气管中测定了这4种药物对异丙肾上腺素的pA 2值（分别对β1-和β2-肾上腺素受体）。2当使用浓度为2 nmol/l的普萘洛尔和阿替洛尔时，可显著抑制肾素释放（P < 0.001和P < 0.01），而普萘洛尔和IPS 339 [叔丁基氨基-3醇-2丙基）肟基-9芴]的影响很小。[3] β1-肾上腺素受体拮抗剂对肾素释放的抑制程度与其pA 2呈正相关。4当以与普萘洛尔等摩尔浓度使用Practolol和IPS 339时，它们抑制β1-肾上腺素受体的肾素释放。5结果提示，参与异丙肾上腺素诱导大鼠肾脏肾素释放的肾上腺素受体为β1-型。
1 The inhibitory effects were studied of 4 β‐adrenoceptor antagonists against renin release induced by isoprenaline (0.5 m̈mol/1) in rat kidney slices. Additionally the pA2 values of these 4 drugs were measured against isoprenaline in guinea‐pig isolated atria and trachea (against β1‐ and β2‐adrenoceptors respectively). 2 When employed at a concentration of 2 nmol/1 propranolol and atenolol significantly inhibited renin release (P < 0.001 and P < 0.01) whereas practolol and IPS 339 [t‐butyl‐amino‐3 ol‐2 propyl) oximino‐9 fluorene] had little effect. 3 A positive correlation was shown between the degree of inhibition of renin release and the pA2 of the antagonists at the β1‐adrenoceptors. 4 When practolol and IPS 339 were used in equipotent molar concentrations to propranolol for the β1‐adrenoceptors they inhibited renin release. 5 The results suggest that the adrenoceptor involved in the renin release induced by isoprenaline in the rat kidney is of the β1‐type.