HAND-FOOT-AND-MOUTH SYNDROME IN HUMANS - COXSACKIE A10 INFECTIONS IN NEW ZEALAND
HAND-FOOT-AND-MOUTH SYNDROME IN HUMANS - COXSACKIE A10 INFECTIONS IN NEW ZEALAND
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DOI：
10.1136/bmj.2.5606.661
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发表时间：
1968-01-01
影响因子：
105.7
通讯作者：
DUFF, MF
中科院分区：
文献类型：
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作者：
DUFF, MF
在25名男性和25名女性健康中年受试者中研究了循环纤溶酶原激活物的静息水平（通过优球蛋白溶解时间测量）和标准运动程序后的变化。女性组的水平明显较高。与50名18-30岁的年轻健康受试者的先前结果相比，两个年龄组之间无统计学显著差异。有证据表明，吸烟可能对循环纤溶酶原激活剂的静息水平有有害影响。运动后纤溶反应差的现象，以前在青年人中描述的，在中年人群中也被发现。中年女性的反应显著高于中年男性，但总的青年和中年人群之间没有显著差异。吸烟对运动引起的纤溶反应没有影响。一项对18名中年受试者进行的为期12个月的随访研究证实了运动对纤维蛋白溶解反应不良的现象。我们要感谢我们热情的献血者群体;东南苏格兰地区输血中心主任RA Cumming博士对他的持续关注和有益的建议; K. W.唐纳德，大学医学系，跑步机设施; E. Robertson和她的工作人员，他们负责招募献血者;乔治·艾伦，M小姐。纽比格和P斯科特小姐的技术援助。我还要感谢N博士。姆克林，爱丁堡西部总医院的病理学家，他允许我们引用他的尸检报告。这项研究计划得到了苏格兰医院捐赠研究信托基金的资助。
The resting levels of circulating plasminogen activator, as measured by the euglobulin lysis time, and changes following a standard exercise procedure were studied in 25 male and 25 female healthy middle-aged subjects. There was a significantly higher level in the female group. Comparison with previous results obtained from 50 young healthy subjects aged 18-30 years showed no statistically significant difference between the two age groups. There was evidence to indicate that cigarette smoking may have a deleterious effect on the resting levelof circulating plasminogen activator. The phenomenon of the poor fibrinolytic responder to exer-cise, previously described in the young subjects, was also shown in the middle-aged population. The middle-aged females had a significantly higher response than the middle-aged males, but there was no significant difference between the total young and middle-aged populations. Cigarette smoking had no influence on the fibrinolytic response to exercise. A 12-month follow-up study on 18 middle-aged subjects confirmed the phenomenon of a poor fibrinolytic response to exercise.We wish to thank our enthusiastic group of blood donors; Dr. RA Cumming, Director of the South-east Scotland Regional Blood Transfusion Centre, for his sustained interest and helpful advice; Professor K. W. Donald, University Department of Medicine, for treadmill facilities; Dr. A. E. Robertson and her staff, who were responsible for the recruiting of the blood donors; and Mr. A. GE Allan, Miss M. Newbigging, and Miss P. Scott for their technical assistance. Our thanks are also due to Dr. N. McLean, pathologist of the Western General Hospital, Edinburgh, who permitted us to quote his necropsy report. This research programme was supported by a grant from the Scottish Hospital Endowments Research Trust.