Gut-immune-brain dysfunction in Autism: Importance of sex.
Gut-immune-brain dysfunction in Autism: Importance of sex.
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DOI：
10.1016/j.brainres.2018.01.009
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发表时间：
2018-08-15
期刊：
影响因子：
2.9
通讯作者：
Bilbo SD
中科院分区：
文献类型：
--
作者：
Kopec AM;Fiorentino MR;Bilbo SD
自闭症谱系障碍（ASD）的特征是社会行为缺陷，刻板，认知僵化，在某些情况下严重的智力障碍和发育迟缓。虽然ASD最广泛地通过其神经功能缺损来识别，但ASD中胃肠道问题很常见。肠道、免疫系统和大脑之间存在着密切而复杂的关系，这导致了一种假设，即ASD可能是一种影响肠道和免疫系统以及大脑的系统水平疾病。尽管在理解肠道和免疫系统对ASD病因学的贡献方面取得了重大进展，但患者中有一个有趣的共同点尚未得到很好的理解：他们主要是男性。事实上，没有人注意到ASD中肠道，外周和中枢免疫功能的性别特异性调节的潜在作用，尽管这种疾病中的男女比例为4：1。在这篇综述中，我们讨论了最近的启示关于肠道免疫脑的关系对啮齿动物模型和ASD患者的社会行为的影响，将它们放置在已知的或假定的性别特异性机制的背景下。
Autism Spectrum Disorder (ASD) is characterized by social behavior deficits, stereotypies, cognitive rigidity, and in some cases severe intellectual impairment and developmental delay. Although ASD is most widely identified by its neurological deficits, gastrointestinal issues are common in ASD. An intimate and complex relationship exists between the gut, the immune system, and the brain, leading to the hypothesis that ASD may be a systems-level disease affecting the gut and immune systems, in addition to the brain. Despite significant advances in understanding the contribution of the gut and immune systems to the etiology of ASD, there is an intriguing commonality among patients that is not well understood: they are predominantly male. Virtually no attention has been given to the potential role of sex-specific regulation of gut, peripheral, and central immune function in ASD, despite the 4:1 male-to-female bias in this disorder. In this review, we discuss recent revelations regarding the impact of gut-immune-brain relationships on social behavior in rodent models and in ASD patients, placing them in the context of known or putative sex specific mechanisms.
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影响因子：
6.2
作者：
Fiorentino M;Sapone A;Senger S;Camhi SS;Kadzielski SM;Buie TM;Kelly DL;Cascella N;Fasano A
通讯作者：
Fasano A
影响因子：
64.8
作者：
Kim S;Kim H;Yim YS;Ha S;Atarashi K;Tan TG;Longman RS;Honda K;Littman DR;Choi GB;Huh JR
通讯作者：
Huh JR
微生物群转移疗法改变肠道生态系统并改善胃肠道和自闭症症状：一项开放标签研究。
影响因子：
15.5
作者：
Kang DW;Adams JB;Gregory AC;Borody T;Chittick L;Fasano A;Khoruts A;Geis E;Maldonado J;McDonough-Means S;Pollard EL;Roux S;Sadowsky MJ;Lipson KS;Sullivan MB;Caporaso JG;Krajmalnik-Brown R
通讯作者：
Krajmalnik-Brown R
DOI：
10.1523/jneurosci.1268-12.2013
发表时间：
2013-02-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lenz KM;Nugent BM;Haliyur R;McCarthy MM
通讯作者：
McCarthy MM
影响因子：
5.3
作者：
Bilbo, SD;Biedenkapp, JC;Maier, SF
通讯作者：
Maier, SF