Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila
Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila
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DOI：
10.1126/science.1127215
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发表时间：
2006-08-11
期刊：
影响因子：
56.9
通讯作者：
Preat, Thomas
中科院分区：
文献类型：
--
作者：
Didelot, Gerard;Molinari, Florence;Preat, Thomas
人类神经胰蛋白酶基因突变与常染色体隐性遗传性精神发育迟滞有关。为了进一步了解缺乏这种丝氨酸蛋白酶的病理生理后果，我们研究了龙舌兰酒（Teq），果蝇神经胰蛋白酶的直系同源物，使用联想记忆作为行为读出。我们发现，teq失活导致长期记忆（LTM）的具体缺陷。野生型苍蝇的LTM条件后，teq表达瞬时增加的蘑菇体。此外，teq表达在成年蘑菇体的特异性抑制导致可逆的LTM缺陷。因此，Teq通路对于果蝇的信息处理至关重要。
Mutations in the human neurotrypsin gene are associated with autosomal recessive mental retardation. To further understand the pathophysiological consequences of the lack of this serine protease, we studied Tequila (Teq), the Drosophila neurotrypsin ortholog, using associative memory as a behavioral readout. We found that teq inactivation resulted in a long-term memory (LTM) specific defect. After LTM conditioning of wild-type flies, teq expression transiently increased in the mushroom bodies. Moreover, specific inhibition of teq expression in adult mushroom bodies resulted in a reversible LTM defect. Hence, the Teq pathway is essential for information processing in Drosophila.