Cadmium affects blood pressure and negatively interacts with obesity: Findings from NHANES 1999-2014
Cadmium affects blood pressure and negatively interacts with obesity: Findings from NHANES 1999-2014
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镉会影响血压并与肥胖产生负面影响：NHANES 1999 年至 2014 年的调查结果
DOI：
10.1016/j.scitotenv.2018.06.105
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发表时间：
2018-12-01
影响因子：
9.8
通讯作者：
Wei, Sheng
中科院分区：
文献类型：
--
作者：
Wang, Qi;Wei, Sheng
注意到镉暴露与血压/高血压之间的关联以及镉与体重指数（BMI）之间的相互作用。本研究旨在澄清美国国家健康检查和营养调查（NHANES，1999-2014）八个周期中年龄>= 20岁成年人的大样本（n = 32，791）中的这些不一致之处。以血镉（BCd）和尿镉（UCd）作为镉暴露的生物标志物。建立多元线性/逻辑回归模型，并按性别、种族和BMI类别分层。BCd和BMI之间的相互作用进行了评估的加法和乘法尺度。在黑人女性中，BCd增加两倍分别与收缩压（SBP）和舒张压（DBP）增加0.54 mmHg（95% CI：0.49，0.58）和0.05 mmHg（95% CI：0.04，0.06）相关。在墨西哥裔美国女性中，SBP和DBP分别增加0.92 mmHg（95% CI：0.73，1.11）和0.85 mmHg（95% CI：0.65，1.05）。BCd与高血压有显著相关性（收缩期风险/2倍BCd，OR = 1.31，95% CI：1.07，1.61;舒张期风险/2倍BCd，OR = 1.55，95% CI：1.17，2.05）。在所有个体中，UCd与高血压显著相关（OR = 1.14/2; 95%CI：1.07，1.21）。镉暴露与血压/高血压之间的关联在BMI类别中显示出一些差异。BCd与肥胖之间在收缩期高血压的影响方面存在负相互作用（RERI = -0.30; 95% CI：-0.56，-0.03; OR比值= 0.55; 95% CI：0.35，0.89）。我们的研究结果为镉对美国成年人血压和高血压患病率的影响提供了证据。这些关联显示出性别和种族的差异。镉暴露与肥胖之间的负交互作用影响收缩期高血压风险。(C)2018爱思唯尔B. V.保留所有权利。
Inconsistencies are noted regarding the association between cadmium exposure and blood pressure/hypertension and the interaction between cadmium and body mass index (BMI). This study aims to clarify these inconsistencies in a large sample (n = 32,791) of adults age >= 20 years from eight cycles of the US National Health Examination and Nutrition Survey (NHANES, 1999-2014). The cadmium levels in blood (BCd) and urine (UCd) were used as exposure biomarker. Multiple-linear/logistic regression models were built and stratified by sex, ethnicity and BMI category. The interaction between BCd and BMI was assessed on additive and multiplicative scales. A twofold increase in BCd was associated with 0.54 mm Hg (95% CI: 0.49, 0.58) and 0.05 mm Hg (95% CI: 0.04, 0.06) increases in the systolic blood pressure (SBP) and diastolic blood pressure (DBP), respectively, in black women. The SBP and DBP increased by 0.92 mm Hg (95% CI: 0.73, 1.11) and 0.85 mm Hg (95% CI: 0.65, 1.05), respectively, in Mexican-Am women. Significant associations were found between BCd and hypertension in them (systolic risk per twofold BCd, OR = 1.31; 95% CI: 1.07, 1.61; and diastolic risk per twofold BCd, OR = 1.55; 95% CI: 1.17, 2.05). UCd was significantly associated with hypertension in all individuals (OR = 1.14 per twofold; 95% CI: 1.07, 1.21). The associations between cadmium exposure and blood pressure/hypertension showed some discrepancies across BMI categories. A negative interaction was observed between BCd and obesity with regard to their effects on systolic hypertension (RERI = -0.30; 95% CI: -0.56, -0.03; ratio of ORs = 0.55; 95% CI: 0.35, 0.89). Our findings provided evidence for the effect of cadmium on blood pressure and the prevalence of hypertension in American adults. The associations showed discrepancies by sex and ethnicity. The negative interaction between cadmium exposure and obesity influenced systolic hypertension risk. (C) 2018 Elsevier B.V. All rights reserved.