Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer.
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer.
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Hippo 通路在器官大小控制、组织稳态和癌症中的作用
DOI：
10.1016/j.cell.2015.10.044
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发表时间：
2015-11-05
期刊：
影响因子：
64.5
通讯作者：
Guan KL
中科院分区：
文献类型：
--
作者：
Yu FX;Zhao B;Guan KL
二十年来对多种模式生物的研究已经证实，河马途径是器官大小和组织动态平衡的关键调节因子。通过抑制YAP和TAZ转录共激活子，Hippo途径调节细胞的增殖、凋亡和干性，以响应广泛的细胞外和细胞内信号，包括细胞-细胞接触、细胞极性、机械信号、G蛋白偶联受体的配体和细胞能量状态。河马通路的失调对癌症的发展有重要影响。进一步研究该通路的功能和调控机制将有助于揭开器官大小控制的谜团，并为癌症治疗寻找新的靶点。
Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein coupled receptors, and cellular energy status. Dysregulation of the Hippo pathway exerts a significant impact on cancer development. Further investigation of the functions and regulatory mechanisms of this pathway will help uncovering the mystery of organ size control and identify new targets for cancer treatment.