Potential involvement of the mitochondrial unfolded protein response in depressive-like symptoms in mice
Potential involvement of the mitochondrial unfolded protein response in depressive-like symptoms in mice
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DOI：
10.1016/j.neulet.2015.01.006
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发表时间：
2015-02-19
影响因子：
2.5
通讯作者：
Miyata, Atsuro
中科院分区：
文献类型：
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作者：
Kambe, Yuki;Miyata, Atsuro
许多证据强烈表明，线粒体缺陷与重度抑郁症有关。线粒体缺陷导致线粒体应激反应，包括线粒体未折叠蛋白反应（UPRmt），这与某些脑部疾病有关，如痉挛性截瘫和帕金森病。然而，没有证据表明抑郁症与UPRmt之间存在关系。慢性约束应激小鼠在悬尾和强迫游泳试验中表现出明显的抑郁样行为，耗氧量降低，与UPRmt相关的Hspa9、Hspd1、Ubl5、Abcb10和ClpP水平升高。在强迫游泳测试中，所有与uprt相关的分子都与抑郁样行为显著相关。因此，本研究旨在揭示UPRmt与抑郁症之间的关系，提示UPRmt是治疗抑郁症的潜在药物靶点。2015爱思唯尔爱尔兰有限公司版权所有。
Many evidences strongly suggest that a mitochondrial deficit is implicated in major depression. A mitochondrial deficit leads to mitochondrial stress responses, including the mitochondrial unfolded protein response (UPRmt), which is associated with certain brain disorders such as spastic paraplegia and Parkinson's disease. However, there is no evidence regarding the relationship between depressive disorder and UPRmt. Mice treated with chronic restraint stress showed significant depressive-like behaviors in the tail suspension and forced swim tests, decreased oxygen consumption rate, and increased levels of molecules associated with UPRmt such as Hspa9, Hspd1, Ubl5, Abcb10, and ClpP. All of the UPRmt-related molecules were significantly correlated with depressive-like behavior in the forced swim test. Thus, the present study is to reveal a relationship between the UPRmt and depressive disorder, suggesting that the UPRmt is a potential drug target for depressive disorders. (C) 2015 Elsevier Ireland Ltd. All rights reserved.