Awareness of olfactory deficits in healthy aging, amnestic mild cognitive impairment and Alzheimer's disease
Awareness of olfactory deficits in healthy aging, amnestic mild cognitive impairment and Alzheimer's disease
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DOI：
10.1017/s1041610210002371
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发表时间：
2011-09-01
影响因子：
7
通讯作者：
Savage, Greg
中科院分区：
文献类型：
--
作者：
Bahar-Fuchs, Alex;Moss, Simon;Savage, Greg
背景资料：嗅觉功能障碍存在于早期阿尔茨海默病（AD）中，并且现在已经报道在患有遗忘型轻度认知障碍（aMCI）的人中。最近的证据表明，没有意识到嗅觉缺陷可能会预测哪些MCI患者随后会符合AD标准。然而，重要的方法上的限制挑战这一建议。虽然解决了一些以前的研究的局限性，本初步研究探讨了不知道嗅觉缺陷作为未来的AD的预测因素与aMCI.Methods的人：25名参与者与aMCI，25 AD患者，和22名健康的老年人参与者进行了嗅觉识别测试。还获得了关于嗅觉检测和嗅觉识别感知下降的主观报告。一个子集的参与者进行了重新评估12个月last.Results：对照组的参与者表现优于aMCI和AD患者的嗅觉识别。几乎一致地，参与者没有报告嗅觉检测或识别的下降。嗅觉功能的主观报告的嗅觉识别分数预测是穷人，嗅觉下降的意识没有关系的可能性aMCI患者进展为AD的12个月的review.Conclusions：治疗意识的嗅觉功能作为一个单一的结构可能会产生误导，有一个嗅觉能力的主观和客观的措施之间的关系不佳。我们的初步数据表明，嗅觉下降的意识不提高识别MCI患者谁更可能是在AD的前驱期。需要在更大的队列中进行复制以支持这些发现。
Background: Olfactory dysfunction is present in early Alzheimer's disease (AD), and has now been reported in people with amnestic mild cognitive impairment (aMCI). Recent evidence suggests that unawareness of an olfactory deficit may predict which MCI patients will subsequently meet AD criteria. However, important methodological limitations challenge this suggestion. While addressing some of the limitations of previous research, this preliminary study explores unawareness of olfactory deficits as a predictive factor of future AD among people with aMCI.Methods: Twenty-five participants with aMCI, 25 AD patients, and 22 healthy elderly participants underwent testing of olfactory identification. Subjective reports regarding perceived decline in olfactory detection and olfactory identification were also obtained. A subset of participants was reassessed 12 months later.Results: Control participants performed better than both aMCI and AD patients on olfactory identification. Almost uniformly, participants did not report decline in either olfactory detection or identification. Prediction of olfactory identification scores from subjective reports of olfactory function was poor, and awareness of olfactory decline bore no relationship to the likelihood of aMCI patients progressing to AD by the 12-month review.Conclusions: Treating awareness of olfactory function as a unitary construct can be misleading, and there is a poor relationship between subjective and objective measures of olfactory ability. Our preliminary data suggest that unawareness of olfactory decline does not improve the identification of patients with MCI who are more likely to be in the prodromal phase of AD. Replication in a larger cohort is needed to support these findings.