The effects of combined superior temporal polysensory area and frontal eye field lesions on eye movements in the macaque monkey.
The effects of combined superior temporal polysensory area and frontal eye field lesions on eye movements in the macaque monkey.
复制标题
颞上多感觉区和额眼区联合损伤对猕猴眼球运动的影响。
DOI：
10.1016/s0166-4328(96)00131-3
复制
发表时间：
1997
影响因子：
2.7
通讯作者：
Gross,CG
中科院分区：
文献类型：
--
作者：
Scalaidhe,SP;Rodman,HR;Albright,TD;Gross,CG
我们先前发现[42]，上颞叶多感觉区(STP)的损伤会导致眼球运动产生暂时性缺陷。为了确定参与随后恢复的区域，并进一步探索皮质对眼球运动的控制，我们研究了在STP病变的基础上增加额部眼场(FEF)损害对视觉注视、眼跳运动和顺畅追逐眼球运动的影响。三只猴子接受了双侧STP损伤，然后是FEF损伤，作为对照，另一只猴子接受了双侧颞叶下皮质(IT)损伤，然后是FEF损伤。所有动物在中央视点凹陷方面都有严重的损害。通过打开测试室中昏暗的灯光，这种损害完全消除。只有在STP和FEF联合损伤后，才能看到在进行眼跳时出现大的疏忽样损害。在STP和FEF联合损伤后，在进行平稳追踪眼球运动方面的损害比STP损伤后更大，但在单独FEF损伤后已报道的缺陷范围内。黑暗中视觉注视的损害和昏暗照明条件下的损害似乎反映了在没有视觉标志的情况下FEF在空间定向中的特殊作用。在顺利追捕方面，FEF似乎也比STP发挥着更关键的作用。相比之下，STP和FEF在产生眼跳方面似乎是协同工作的。我们认为，皮层眼动控制可以通过中脑，也可以通过FEF，FEF通路专门参与刺激和行为反应不连续的任务，而中脑通路优先参与更多刺激驱动的眼球运动。
We previously found [42] that lesions of the superior temporal polysensory area (STP) cause temporary deficits in the production of eye movements. In order to both define regions participating in the ensuing recovery and to further explore the cortical control of eye movements, we examined the effects of addition of frontal eye field (FEF) lesions to STP lesions, on visual fixation, saccadic eye movements, and smooth pursuit eye movements. Three monkeys received bilateral STP lesions followed by a FEF lesion and as a control, an additional monkey received a bilateral inferior temporal cortex (IT) lesion followed by a FEF lesion. All animals had a profound impairment in foveating the central fixation point. This impairment was completely eliminated by turning on a dim light in the testing chamber. Large neglect-like impairments in making saccades were only seen after combined STP and FEF lesions. Impairments in making smooth pursuit eye movements after combined lesions of STP and FEF were larger than those seen after STP lesions but within the range of deficits that have been reported after FEF lesions alone. The impairment of visual fixation in darkness and the lack of impairment under conditions of dim illumination appear to reflect a specific role for the FEF in spatial orientation in the absence of visual landmarks. The FEF also appears to play a more critical role than STP in smooth pursuit. By contrast, STP and the FEF appear to work cooperatively with respect to the production of saccades. We suggest that cortical oculomotor control can flow either through the midbrain or through the FEF and that the FEF pathway is specifically involved in tasks with a discontiguity between the stimuli and the behavioral response while the midbrain pathways are preferentially involved in more stimulus-driven eye movements.