Platelet reactivity in twin pregnancies
Platelet reactivity in twin pregnancies
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DOI：
10.1016/j.thromres.2015.12.019
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发表时间：
2016-02-01
影响因子：
7.5
通讯作者：
Minakami, Hisanori
中科院分区：
文献类型：
--
作者：
Umazume, Takeshi;Yamada, Takahiro;Minakami, Hisanori
背景：双胎妊娠比单胎妊娠更容易发生血小板减少症。然而，目前还不清楚血小板是否是更积极的双胞胎比singletonpregnances.Methods：自发血小板聚集和伴随血小板计数下降的变化进行了检查超过90分钟后，血液采样在171和52枸橼酸全血（CWB）样本从59和17名妇女单胎和双胎妊娠，分别。可溶性p选择素同时测定血浆sP-选择素水平。妊娠中期采血后60 min CWB显示血小板聚集体数量显著增加（1297 +/- 1600 vs. 497 +/- 432/mu l，P = 0.040），同时双胎妊娠的血小板计数净下降（152 +/- 55 vs. 115 +/- 45 x 10（9）/mu l，P = 0.036）显著大于单胎妊娠。其次是双胎妊娠的第三孕期血小板计数显著低于单胎妊娠（181 +/- 43 vs. 229 +/- 62 x 10（9）/l，P = 0.009），平均血小板体积显著高于单胎妊娠（8.0 +/- 1.2 vs. 7.1 +/- 1.1 fl，P = 0.021）。结论：双胎妊娠中晚期血小板反应性高于单胎妊娠。这种增强的血小板反应性可以解释双胎妊娠晚期血小板计数下降的原因。(C)2016爱思唯尔有限公司版权所有。
Background: Gestational thrombocytopenia is more likely to occur in twin than singleton pregnancies. However, it is unclear whether platelets are more reactive in twin than singleton pregnancies.Methods: Changes in spontaneous platelet aggregation and concomitant fall in platelet count were examined over 90 min after blood sampling in 171 and 52 citrated whole blood (CWB) samples from 59 and 17 women with singleton and twin pregnancies, respectively. Soluble P-selectin (sP-selectin) levels in the plasma were also determined.Results: CWB 60 min after blood sampling during 2nd trimester exhibited significantly larger numbers of platelet aggregates (1297 +/- 1600 vs. 497 +/- 432/mu l, P = 0.040) concomitant with significantly greater net decrease in platelet count (152 +/- 55 vs. 115 +/- 45 x 10(9)/mu l, P = 0.036) in twin than singleton pregnancies, respectively. This was followed by significantly lower 3rd trimester platelet count (181 +/- 43 vs. 229 +/- 62 x 10(9)/l, P = 0.009) with significantly greater mean platelet volume (8.0 +/- 1.2 vs. 7.1 +/- 1.1 fl, P = 0.021) in twin than singleton pregnancies, respectively. The 3rd trimester sP-selectin per platelet was significantly higher in twin than singleton pregnancies.Conclusions: Platelets were more reactive in the 2nd trimester of twin than singleton pregnancies. This enhanced platelet reactivity may explain the decreased platelet count in the 3rd trimester of twin pregnancy. (C) 2016 Elsevier Ltd. All rights reserved.