Regulation of body pigmentation by the abdominal-B Hox protein and its gain and loss in Drosophila evolution
Regulation of body pigmentation by the abdominal-B Hox protein and its gain and loss in Drosophila evolution
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DOI：
10.1016/j.cell.2006.04.043
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发表时间：
2006-06-30
期刊：
影响因子：
64.5
通讯作者：
Carroll, Sean B.
中科院分区：
文献类型：
--
作者：
Jeong, Sangyun;Rokas, Antonis;Carroll, Sean B.
Hox基因与许多动物身体模式的进化有关，但性状改变背后的分子事件尚未阐明。雄性腹部后部的色素沉着是果蝇谱系中最近获得的特征。在这里，我们发现 Abdominal-B (ABD-B) Hox 蛋白直接激活后段黄色色素沉着基因的表达。 ABD-B 对色素沉着的调节是通过获得两性二态性物种共同祖先的黄色基因的特定顺式调节元件中的 ABD-B 结合位点而进化的。在黑腹果蝇物种组中，雄性特异性色素沉着随后因至少三种不同的机制而消失，包括一个谱系中关键 ABD-B 结合位点的突变失活。这些结果证明了 Hox 对性状和目标基因的调节如何在物种水平上获得和丧失，并对更高分类水平上的体型进化具有一般意义。
Hox genes have been implicated in the evolution of many animal body patterns, but the molecular events underlying trait modification have not been elucidated. Pigmentation of the posterior male abdomen is a recently acquired trait in the Drosophila melanogaster lineage. Here, we show that the Abdominal-B (ABD-B) Hox protein directly activates expression of the yellow pigmentation gene in posterior segments. ABD-B regulation of pigmentation evolved through the gain of ABD-B binding sites in a specific cis-regulatory element of the yellow gene of a common ancestor of sexually dimorphic species. Within the melanogaster species group, male-specific pigmentation has subsequently been lost by at least three different mechanisms, including the mutational inactivation of a key ABD-B binding site in one lineage. These results demonstrate how Hox regulation of traits and target genes is gained and lost at the species level and have general implications for the evolution of body form at higher taxonomic levels.