Syntheses and diuretic activity of 1,2-dihydro-2-(3-pyridyl)-3H-pyrido[2,3-d]pyrimidin-4-one and related compounds.
Syntheses and diuretic activity of 1,2-dihydro-2-(3-pyridyl)-3H-pyrido[2,3-d]pyrimidin-4-one and related compounds.
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DOI：
10.1021/jm00343a022
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发表时间：
1982
影响因子：
7.3
通讯作者：
H. Parish;R. D. Gilliom;W. P. Purcell;R. Browne;R. F. Spirk;H. D. White
中科院分区：
文献类型：
--
作者：
H. Parish;R. D. Gilliom;W. P. Purcell;R. Browne;R. F. Spirk;H. D. White
制备了标题化合物 5，并发现它对大鼠来说是一种有效的利尿剂。在27mg/kg时，尿量是盐水对照的250%，并且电解质的排泄与氢氯噻嗪对照相似。在80mg/kg时，钾的排泄与盐水对照相同，钠和氯的排泄增加了一倍多。制备并测试了几种类似物。有些表现出利尿活性。
The title compound, 5, was prepared and found to be a potent diuretic in the rat. At 27 mg/kg, urine output was 250% of the saline control, and the excretion of electrolytes was similar to th^ hydrochlorothiazide control. At 80 mg/kg, the potassium excretion was the same as the saline control, and the sodium and chloride excretions more than doubled. Several analogues were prepared and tested. Some show diuretic activity.