The function of myostatin in the regulation of fat mass in mammals.
The function of myostatin in the regulation of fat mass in mammals.
复制标题
肌肉生长抑制素在哺乳动物脂肪量调节中的作用
DOI：
10.1186/s12986-017-0179-1
复制
发表时间：
2017
影响因子：
4.5
通讯作者：
Jiang S
中科院分区：
文献类型：
--
作者：
Deng B;Zhang F;Wen J;Ye S;Wang L;Yang Y;Gong P;Jiang S
肌肉生长抑制素(MSTN)又称生长分化因子-8，是一种在肌肉组织中分泌的蛋白质。研究人员认为，它的主要功能是负向调节肌肉，因为它编码区的突变可以导致牛著名的双重肌肉特征。肌肉和脂肪组织由同一间充质干细胞发育而来，研究人员发现，MSTN在脂肪组织中表达，在脂肪形成中发挥关键作用。有趣的是，根据情况，MSTN可以发挥双重功能，要么抑制脂肪生成，要么促进脂肪生成。由于其在控制体内脂肪质量方面的潜在功能，MSTN引起了研究人员的兴趣。在这篇综述中，我们探讨了它在哺乳动物脂肪生成调控中的作用，包括前脂肪细胞、多能干细胞和脂肪团。
Myostatin (MSTN), also referred to as growth and differentiation factor-8, is a protein secreted in muscle tissues. Researchers believe that its primary function is in negatively regulating muscle because a mutation in its coding region can lead to the famous double muscle trait in cattle. Muscle and adipose tissue develop from the same mesenchymal stem cells, and researchers have found that MSTN is expressed in fat tissues and plays a key role in adipogenesis. Interestingly, MSTN can exert a dual function, either inhibiting or promoting adipogenesis, according to the situation. Due to its potential function in controlling body fat mass, MSTN has attracted the interest of researchers. In this review, we explore its function in regulating adipogenesis in mammals, including preadipocytes, multipotent stem cells and fat mass.