POLYARTHRITIS IN RATS FOLLOWING THE SYSTEMIC INJECTION OF LACTOBACILLUS-CASEI CELL-WALLS IN AQUEOUS SUSPENSION
POLYARTHRITIS IN RATS FOLLOWING THE SYSTEMIC INJECTION OF LACTOBACILLUS-CASEI CELL-WALLS IN AQUEOUS SUSPENSION
复制标题
DOI：
10.1002/art.1780261013
复制
发表时间：
1983-01-01
影响因子：
--
通讯作者：
WILDER, RL
中科院分区：
文献类型：
--
作者：
LEHMAN, TJA;ALLEN, JB;WILDER, RL
直肠后Reiter综合征和与空肠旁路手术治疗肥胖相关的关节炎表明，胃肠道可能是能够引发慢性炎性关节炎的细菌产物的来源。L.酪蛋白是肠道植物群的常见成分，其细胞壁结构与致关节炎链球菌的细胞壁结构相似。在这项研究中，证明了单次腹腔注射L.酪蛋白在近交系LEW/N雌性大鼠中诱导剂量依赖性、慢性、对称性、侵蚀性、外周性多关节炎。显然，正常肠道植物群中的细菌可能是能够诱导慢性侵蚀性多关节炎的炎症产物的来源。
Postdysenteric Reiter''s syndrome and the arthritis associated with jejunal bypass surgery for obesity suggest that the gastrointestinal tract is a possible source of bacterial products capable of initiating chronic inflammatory arthritis. L. casei, a common component of the enteric flora, has a cell wall structure similar to that of arthritogenic streptococci. In this study it was demonstrated that a single i.p. injection of an aqueous suspension of the cell walls of L. casei induces a dose-dependent, chronic, symmetric, erosive, peripheral polyarthritis in inbred LEW/N female rats. Evidently, bacteria in the normal enteric flora may be a source of inflammatory products capable of inducing chronic erosive polyarthritis.