Real-time fluorescence-enhanced imaging as an aid to surgery in ovarian cancer
Real-time fluorescence-enhanced imaging as an aid to surgery in ovarian cancer
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DOI：
10.1109/jstqe.2007.910998
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发表时间：
2007-11-01
影响因子：
4.9
通讯作者：
Choyke, Peter L.
中科院分区：
文献类型：
--
作者：
Longmire, Michelle R.;Gunn, Andrew J.;Choyke, Peter L.
上皮性卵巢癌在所有妇科癌症中死亡率最高。由于其症状的非特异性，大多数患有卵巢癌的女性都表现为晚期疾病，导致整体预后不良。手术肿瘤减积是改善这些患者预后的最有效干预措施之一。然而，将残留肿瘤的量减少到微观水平通常由于植入物的小尺寸以及在大多数手术室中发现的白色光条件下小肿瘤植入物和正常组织之间的视觉对比度差而变得复杂。因此，一种改进转移性卵巢癌切除术的方法是应用肿瘤靶向光学荧光孔，其可以以高灵敏度和特异性识别转移部位，为外科医生提供术中肿瘤定位指南。在此，我们描述了一种使用荧光标记和实时荧光摄像机识别卵巢癌转移的新方法，该方法允许切除转移性疾病，否则外科医生无法看到。
Epithelial ovarian cancer has the highest mortality among all gynecologic cancers. Due to the nonspecific nature of its symptoms, most women with ovarian cancer present with advanced stage disease, resulting in a poor overall prognosis. Surgical tumor debulking is one of the most effective interventions to improve the outcome for these patients. However, reducing the amount of residual tumor to microscopic levels is often complicated by the small size of the implants and poor visual contrast between small tumor implants and normal tissue under white light conditions found in most operating rooms. Therefore, one proposed method to improve the resection of metastatic ovarian cancer is to apply tumor-targeted optical fluoropbores that could identify sites of metastasis with high sensitivity and specificity, providing the surgeon with an intraoperative guide to tumor location. Herein, we describe a novel method of identifying ovarian cancer metastases using fluorescent tagging and a real-time fluorescence camera that allows the resection of metastatic disease that would otherwise not be visible to the surgeon.