Synergy of a hepatitis C virus (HCV) NS4A antagonist in combination with HCV protease and polymerase inhibitors.
Synergy of a hepatitis C virus (HCV) NS4A antagonist in combination with HCV protease and polymerase inhibitors.
复制标题
丙型肝炎病毒 (HCV) NS4A 拮抗剂与 HCV 蛋白酶和聚合酶抑制剂联合使用的协同作用。
DOI：
10.1128/aac.01208-07
复制
发表时间：
2008
影响因子：
4.9
通讯作者：
Schooley,RobertT
中科院分区：
文献类型：
--
作者：
Wyles,DavidL;Kaihara,KellyA;Schooley,RobertT
Rapid emergence of resistance to monotherapy with virus-specific inhibitors necessitates combination therapy. ACH-806 is a hepatitis C virus NS4A inhibitor with a novel mechanism of action and resistance pathway. This compound was synergistic with NS3 protease inhibitors and NS5B nucleoside and nonnucleoside polymerase inhibitors.
