Correlation Between Brain Activation Changes and Cognitive Improvement Following Cognitive Remediation Therapy in Schizophrenia: An Activation Likelihood Estimation Meta-analysis.
Correlation Between Brain Activation Changes and Cognitive Improvement Following Cognitive Remediation Therapy in Schizophrenia: An Activation Likelihood Estimation Meta-analysis.
复制标题
精神分裂症认知矫正治疗后大脑激活变化与认知改善之间的相关性：激活可能性估计荟萃分析
DOI：
10.4103/0366-6999.176983
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发表时间：
2016-03-05
影响因子：
6.1
通讯作者：
Tang YX
中科院分区：
文献类型：
--
作者：
Wei YY;Wang JJ;Yan C;Li ZQ;Pan X;Cui Y;Su T;Liu TS;Tang YX
背景：多项使用功能磁共振成像(FMRI)和正电子发射断层扫描(PET)的研究表明，认知修复疗法(CRT)可能通过改变精神分裂症患者的脑激活来改善认知功能。然而，在不同的研究中，这些变化的大脑区域的结果并不一致。采用激活似然估计(ALE)Meta分析方法，探讨CRT治疗后精神分裂症患者认知功能改变是否伴随脑激活改变，以及与这些改变最相关的区域在哪里。比较了全脑研究和全脑+感兴趣区(ROI)研究的分析，以探讨不同方法对结果的影响。方法：通过计算机系统检索，收集精神分裂症患者CRT治疗前后脑活动变化的fMRI和PET研究资料。9项使用功能磁共振成像技术的研究被纳入荟萃分析。使用Ginger ALE 2.3.1对这些成像研究进行荟萃分析。结果：CRT后脑活动增强的脑区主要在额叶和顶叶，包括左侧额内侧回、左侧额下回、右侧额中回、右侧中央后回和顶下小叶，但未发现脑活动减少。尽管在有或没有ROI研究的ALE中发现了类似的激活增加的脑区，但包括ROI研究在内的分析具有更高的ALE价值。结论：CRT可能通过增加额叶和顶叶的激活来改善精神分裂症患者的认知功能。此外，通过将ROI研究纳入ALE荟萃分析，可能会提供更多的证据来证实结果。
Background: Several studies using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) have indicated that cognitive remediation therapy (CRT) might improve cognitive function by changing brain activations in patients with schizophrenia. However, the results were not consistent in these changed brain areas in different studies. The present activation likelihood estimation (ALE) meta-analysis was conducted to investigate whether cognitive function change was accompanied by the brain activation changes, and where the main areas most related to these changes were in schizophrenia patients after CRT. Analyses of whole-brain studies and whole-brain + region of interest (ROI) studies were compared to explore the effect of the different methodologies on the results. Methods: A computerized systematic search was conducted to collect fMRI and PET studies on brain activation changes in schizophrenia patients from pre- to post-CRT. Nine studies using fMRI techniques were included in the meta-analysis. Ginger ALE 2.3.1 was used to perform meta-analysis across these imaging studies. Results: The main areas with increased brain activation were in frontal and parietal lobe, including left medial frontal gyrus, left inferior frontal gyrus, right middle frontal gyrus, right postcentral gyrus, and inferior parietal lobule in patients after CRT, yet no decreased brain activation was found. Although similar increased activation brain areas were identified in ALE with or without ROI studies, analysis including ROI studies had a higher ALE value. Conclusions: The current findings suggest that CRT might improve the cognition of schizophrenia patients by increasing activations of the frontal and parietal lobe. In addition, it might provide more evidence to confirm results by including ROI studies in ALE meta-analysis.