CHANGES IN SERUM IRON LEVELS DUE TO INFECTION WITH HEPATITIS-B VIRUS
CHANGES IN SERUM IRON LEVELS DUE TO INFECTION WITH HEPATITIS-B VIRUS
复制标题
DOI：
10.1073/pnas.78.5.3222
复制
发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
WHITFORD, PL
中科院分区：
文献类型：
--
作者：
BLUMBERG, BS;LUSTBADER, ED;WHITFORD, PL
大量终末期肾病患者接受肾透析随访10年。1个月后患者的血清Fe和SGPT [血清-L-丙氨酸2-酮戊二酸转氨酶，EC 2.6.1.2]水平感染前，感染后，但在mo内。感染后6-12个月。感染后的描述。比较血清铁水平之间的那些感染谁保留病毒（载体）和那些拒绝感染（瞬态）。在感染前，这些组之间没有差异。血清铁在携带者组中保持高水平，在瞬态中下降。并不是所有的携带者都保持高水平，尽管这是一般情况。然后考虑转换前和转换后时期的个体变化。所有携带者谁有一个转换前下降铁增加感染后，这只发生在一些瞬态。那些在感染后下降的携带者在感染前上升了水平;下降的幅度通常小于增加的幅度。因此，铁的升高可能独立于SGPT的升高。从这些发现中得出了几个假设。一般来说，携带者的铁水平较高，因此更容易感染细菌;这可能导致发病率和死亡率增加。从实验证据来看，Fe是肿瘤细胞生长所必需的。铁水平升高的携带者可能比那些没有铁水平的携带者更有可能发展出可检测的肝癌。
A large number of patients with end-stage renal disease receiving renal dialysis were followed for 10 yr. Serum Fe and SGPT [serum-L-alanine 2-oxoglutarate aminotransferase, EC 2.6.1.2] levels in patients 1 mo. before infection, after infection but within the mo. of infection and 6-12 mo. after infection are described. Comparisons of serum Fe levels were made between those infected who retained the virus (carriers) and those who rejected the infection (transients). There were no differences between these groups before infection. Serum Fe remained high in the carrier group and dropped in the transients. Not all of the carriers retained high levels, although this was the case in general. Individual changes in the pre- and postconversion period were then considered. All carriers who had a preconversion decline in Fe had an increase after infection; this occurred in only some of the transients. Those carriers who had a decline after infection had raised levels before infection; the decline was generally less than the increase. Thus, elevation of Fe may be independent of rise in SGPT. Several hypotheses were derived from these findings. Individuals who are carriers in general have higher Fe levels and, therefore, are more likely to become infected with bacteria; this may contribute to increased morbidity and mortality. From experimental evidence, Fe is required for the growth of tumor cells. Carriers with elevated Fe levels may be more likely to develop detectable cancer of the liver than those who do not.