RADIOMANGANESE STUDIES ON THE MOUSE, RAT AND PANCREATIC FISTULA DOG
RADIOMANGANESE STUDIES ON THE MOUSE, RAT AND PANCREATIC FISTULA DOG
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DOI：
10.1152/ajplegacy.1952.168.3.620
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发表时间：
1952-01-01
影响因子：
--
通讯作者：
SHEPPARD, CW
中科院分区：
文献类型：
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作者：
BURNETT, WT;BIGELOW, RR;SHEPPARD, CW
静脉注射后Mn 54的定位。admn.标记的MnCl 2显示了小鼠，大鼠和狗。注射前收集的胰液。的Mn溶液。（7 mg.用333 [mu]c的Mn 54标记的Mn）中的每只狗含有5-20 [mu]g。Mn和随后收集的汁液含有5 [mu]g。放射性测量提供了胰腺中锰转换率的估计值。amt的最可能值。每天果汁中锰的出现量为腺体中锰的11%。2小时的活动水平。从时间0开始为每升胰液剂量的1.0%，24小时为0.9%。与2、10、30和60分钟时的24.5、1.2、0.5、0.2和0.05%剂量/升血浆相比，和24小时。从零开始Mn ~（54）产量随饲养时间呈周期性变化，并与蛋白氮产量成正比。使用给予7 mg的犬获得了相似的结果。用541 [mu]c标记的Mn。关于Mn 54因此，由于胰腺组织通常具有高浓度。锰的标记，在果汁中的外观锰似乎是一个分泌过程的结果。
Localization of Mn54 following the intraven. admn. of labeled MnCl2 was shown for mice, rats, and dogs. Pancreatic juice which was collected prior to the injn. of a Mn soln. (7 mg. of Mn labeled with 333 [mu]c of Mn 54) into one dog contained 5-20 [mu]g. of Mn and juice collected subsequently contained 5 [mu]g. Radioactivity measurements provided an estimate of the Mn turnover rate in the pancreas. The most probable value for the amt. of Mn which appeared in the juice per day was 11% of the Mn in the gland. The level of activity at 2 hrs. from time zero was 1.0% of the dose per liter of pancreatic juice and 0.9% at 24 hrs. in contrast to 24.5, 1.2, 0.5, 0.2, and 0.05% of the dose/liter of plasma at 2, 10, 30, and 60 min., and 24 hrs. from time zero. The Mn54 output varied periodically with the feeding schedule and appeared to be proportional to the output of protein N. Similar results were obtained using a dog which was given 7 mg. of Mn labeled with 541 [mu]c. of Mn54. Thus, since pancreatic tissue normally has a high concn. of Mn, the appearance of labeled Mn in the juice seems to be the result of a secretory process.