A total synthesis of spiruchostatin A
A total synthesis of spiruchostatin A
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DOI：
10.1016/j.tetlet.2005.12.031
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发表时间：
2006-02-13
影响因子：
1.8
通讯作者：
Takahashi, T
中科院分区：
文献类型：
--
作者：
Doi, T;Iijima, Y;Takahashi, T
我们完成了组蛋白去乙酰化酶抑制剂spiruchostatin A的全合成，作为其类似物组合文库制备的前奏。两个关键反应是用锆烯醇酯进行的不对称醋酸醛醇反应和用Shiina法进行的大内酯化反应。(c) 2005年Elsevier Ltd出版
We achieved the total synthesis of the histone deacetylase inhibitor spiruchostatin A, as the prelude to the preparation of a combinatorial library of its analogues. Two key reactions were an asymmetric acetate aldol reaction using a Zr-enolate and macrolactonization Using the Shiina method. (c) 2005 Published by Elsevier Ltd.