Static magnetic field stimulation applied over the cervical spinal cord can decrease corticospinal excitability in finger muscle.
Static magnetic field stimulation applied over the cervical spinal cord can decrease corticospinal excitability in finger muscle.
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DOI：
10.1016/j.cnp.2018.02.001
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发表时间：
2018
影响因子：
1.7
通讯作者：
Nakazawa K
中科院分区：
文献类型：
--
作者：
Nakagawa K;Nakazawa K
对颈脊髓进行静磁场刺激。经脊髓静态磁场刺激（tsSMS）可降低MEP振幅。停止干预后，tsSMS的抑制作用不再维持。经颅静态磁场刺激最近被证明可以调节皮质兴奋性。在本研究中，我们研究了经脊髓静电磁场刺激（tsSMS）对皮质脊髓束兴奋性的影响。将一个用于tsSMS的紧凑型磁铁（0.45 Tesla）或一个用于假刺激的不锈钢圆柱体放置在24名健全受试者的颈部（C8水平）上15 min。使用静息运动阈值的120%经颅磁刺激强度，在tsSMS或假干预之前、期间和之后测量第一指骨间肌的运动诱发电位（MEPs）。与基线相比，在tsSMS期间MEP振幅下降，但在假刺激期间没有。此外，在干预期间，tsSMS的MEP振幅低于假刺激，尽管这些影响在干预结束后并不持续。结果表明，用致密磁铁对脊髓进行静态磁场刺激可降低皮质脊髓束的兴奋性。经脊髓静电磁场刺激可能是一种新的无创脊髓神经调节工具。其抑制作用可应用于病理性脊髓神经网络高兴奋性患者。
Static magnetic field stimulation was delivered on cervical spinal cord. Trans-spinal static magnetic field stimulation (tsSMS) decreased MEP amplitudes. The suppressive effect of tsSMS was not maintained after the intervention ceased. Transcranial static magnetic field stimulation has recently been demonstrated to modulate cortical excitability. In the present study, we investigated the effect of transspinal static magnetic field stimulation (tsSMS) on excitability of the corticospinal tract. A compact magnet for tsSMS (0.45 Tesla) or a stainless steel cylinder for sham stimulation was positioned over the neck (C8 level) of 24 able-bodied subjects for 15 min. Using 120% of the resting motor threshold transcranial magnetic stimulation intensity, motor evoked potentials (MEPs) were measured from the first digital interosseous muscle before, during, and after the tsSMS or sham intervention. Compared with baseline MEP amplitudes were decreased during tsSMS, but not during sham stimulation. Additionally, during the intervention, MEP amplitudes were lower with tsSMS than sham stimulation, although these effects did not last after the intervention ceased. The results suggest that static magnetic field stimulation of the spinal cord by a compact magnet can reduce the excitability of the corticospinal tract. Transspinal static magnetic field stimulation may be a new non-invasive neuromodulatory tool for spinal cord stimulation. Its suppressive effect may be applied to patients who have pathological hyperexcitability of the spinal neural network.