ELECTROENCEPHALOGRAM AND VISUAL-EVOKED POTENTIAL GENERATION IN A MATHEMATICAL-MODEL OF COUPLED CORTICAL COLUMNS
ELECTROENCEPHALOGRAM AND VISUAL-EVOKED POTENTIAL GENERATION IN A MATHEMATICAL-MODEL OF COUPLED CORTICAL COLUMNS
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DOI：
10.1007/bf00199471
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发表时间：
1995-09-01
影响因子：
1.9
通讯作者：
RIT, VG
中科院分区：
文献类型：
--
作者：
JANSEN, BH;RIT, VG
这项研究涉及基于神经生理学的模型，模拟脑电活动（即，脑电图或EEG和诱发电位或EP）。一个以前开发的集总参数模型的一个单一的皮质柱实施使用一个更准确的计算程序。确定了各种模型参数的解剖学可接受值，并对模型参数空间进行了多维探索。结果发现，该模型可以产生各种各样的EEG样波形和节奏。耦合两个模型，在互连中延迟以模拟皮层区域内和之间的突触连接，使得复制α和β活动的空间分布成为可能。通过向耦合模型的输入呈现脉冲来模拟EP。总的来说，这些答复比使用单一模型得出的答复更切合实际。我们的模拟还表明，头皮记录的EP至少部分是由于正在进行的活动的相位重排。
This study deals with neurophysiologically based models simulating electrical brain activity (i.e., the electroencephalogram or EEG, and evoked potentials or EPs). A previously developed lumped-parameter model of a single cortical column was implemented using a more accurate computational procedure. Anatomically acceptable values for the various model parameters were determined, and a multi-dimensional exploration of the model parameter-space was conducted. It was found that the model could produce a large variety of EEG-like waveforms and rhythms. Coupling two models, with delays in the interconnections to simulate the synaptic connections within and between cortical areas, made it possible to replicate the spatial distribution of alpha and beta activity. EPs were simulated by presenting pulses to the input of the coupled models. In general, the responses were more realistic than those produced using a single model. Our simulations also suggest that the scalp-recorded EP is at least partially due to a phase reordering of the ongoing activity.