Three types of antibiotics produced from Rhodococcus erythropolis strains
Three types of antibiotics produced from Rhodococcus erythropolis strains
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DOI：
10.1264/jsme2.23.167
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发表时间：
2008-01-01
影响因子：
2.2
通讯作者：
Tamura, Tomohiro
中科院分区：
文献类型：
--
作者：
Kitagawa, Wataru;Tamura, Tomohiro
共有15个红串红球菌菌株被表征为抗生素生产者，并根据其抗生素谱和生长相容性（组内的菌株不抑制彼此的生长）分为三组。每个抗生素组对分类学上不同宽度的细菌表现出抗生素活性：第I组对广泛的革兰氏阳性菌表现出抗生素活性;第II组，主要针对红球菌属和一些其他革兰氏阳性菌;和第IIII组，特别是针对R.红原从液体培养基中部分纯化属于组I和组II的菌株的抗生素化合物。结果发现，每个组产生不同的抗生素。与抗生素活性的多样性相反，在分析的1，440-nt区域中的16 S rRNA基因的序列被发现在所有这15个红球菌菌株中是相同的。除了R.通过对红串菌属菌株的比较，我们阐明了红球菌属产甲烷菌物种的多样性。到目前为止，只有少数抗生素生产菌株已在红球菌的报道，然而，我们的研究结果表明，该属包括不同的抗生素生产商，是一个很好的来源，新的抗生素。
A total of 15 Rhodococcus erythropolis strains were characterized as antibiotic producers and classified into three groups according to their antibiotic spectrum and growth compatibility (strains within a group did not inhibit each other's growth). Each of the antibiotic groups exhibited antibiotic activity against a taxonomically different breadth of bacteria: Group I exhibited antibiotic activity against a broad range of Gram-positives; Group II, mainly against the genus Rhodococcus and some other Gram-positives; and Group IIII, particularly against R. erythropolis. The antibiotic compounds of the strains belonging to Groups I and II were partially purified from liquid culture media. It was found that each group produces distinct antibiotics. In contrast to the diversity of antibiotic activity, the sequence of the 16S rRNA gene in the analyzed 1,440-nt region was found to be identical in all these 15 Rhodococcus strains. In addition to the antibiotic diversity in R. erythropolis strains, we elucidated the diversity in antibiotic-producing species of the genus Rhodococcus. Thus far, only a few anti biotic-producing strains have been reported in Rhodococcus; however, our results demonstrated that the genus comprises diverse antibiotic producers, and is a good source of new antibiotics.