Reduced Neural Habituation in the Amygdala and Social Impairments in Autism Spectrum Disorders
Reduced Neural Habituation in the Amygdala and Social Impairments in Autism Spectrum Disorders
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DOI：
10.1176/appi.ajp.2008.07101681
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发表时间：
2009-04-01
影响因子：
17.7
通讯作者：
Aylward, Elizabeth
中科院分区：
文献类型：
--
作者：
Kleinhans, Natalia M.;Johnson, L. Clark;Aylward, Elizabeth
目的：杏仁核功能障碍被认为是自闭症谱系障碍社交障碍的重要组成部分。本研究旨在探讨是否异常习惯化的特点杏仁核功能障碍的自闭症谱系障碍和杏仁核习惯化的速度是否与社会impairment.Method：使用功能磁共振成像，作者测量了随着时间的变化激活的杏仁核和梭状回中性面部刺激的成年自闭症谱系障碍和健康对照成年人。对照组的双侧杏仁核习惯化程度明显高于自闭症谱系组。在总体梭形习惯方面没有组间差异。对于自闭症谱系障碍组，杏仁核对面部刺激的习惯化水平较低，与更严重的social impairment.Conclusions：这些结果表明，在自闭症谱系障碍的杏仁核过度唤醒在响应社会相关的刺激。此外，持续的杏仁核唤醒可能有助于自闭症谱系障碍中观察到的社会缺陷。
Objective: Amygdala dysfunction has been proposed as a critical component in social impairment in autism spectrum disorders. This study was designed to investigate whether abnormal habituation characterizes amygdala dysfunction in autism spectrum disorders and whether the rate of amygdala habituation is related to social impairment.Method: Using functional MRI, the authors measured change over time in activation of the amygdala and fusiform gyrus to neutral facial stimuli in adults with autism spectrum disorders and healthy comparison adults.Results: The comparison group evidenced significantly greater amygdala habituation bilaterally than the autism spectrum group. There were no group differences in overall fusiform habituation. For the autism spectrum group, lower levels of habituation of the amygdala to the face stimuli were associated with more severe social impairment.Conclusions: These results suggest amygdala hyperarousal in autism spectrum disorders in response to socially relevant stimuli. Further, sustained amygdala arousal may contribute to the social deficits observed in autism spectrum disorders.