Regulation of pulsatile luteinizing hormone release during the estrous cycle and pregnancy in the rat.
Regulation of pulsatile luteinizing hormone release during the estrous cycle and pregnancy in the rat.
复制标题
大鼠动情周期和妊娠期间脉动黄体生成激素释放的调节。
DOI：
10.1007/978-1-4684-5395-9_6
复制
发表时间：
1987
影响因子：
--
通讯作者：
Marco,J
中科院分区：
文献类型：
--
作者：
Gallo,RV;Babu,GN;Bona-Gallo,A;Devorshak-Harvey,E;Leipheimer,RE;Marco,J
在大鼠动情周期（Gallo，1981; Higuchi和Kawakami，1982; Fox和Smith，1985）和妊娠（Gallo等人，1985年，他以一种令人毛骨悚然的方式出现。此外，这种分泌的幅度和频率特性的变化发生在4天发情周期的不同阶段，并在不同阶段的妊娠在这个物种。雌二醇（E2）和孕酮（P）的血浆水平在发情周期中也随阶段而变化（Butcher等人，1974; Kalra和Kalra，1974 b; Smith等人，1975; Nequin等人，1979）以及在大鼠妊娠的不同阶段（Morishige等，1973年; Taya和Greenwald，1981年; Bridges，1984年）。我们工作的重点是在生理背景下研究LH脉冲分泌的神经内分泌调节。因此，我们实验的目的是首先描述整个动情周期和怀孕期间LH脉冲幅度和频率发生的正常变化，然后定义E2和/或P在每个24小时期间的调节负反馈作用。大鼠动情周期和妊娠的特定阶段。
Luteinizing hormone (LH) secretion during the rat estrous cycle (Gallo, 1981; Higuchi and Kawakami, 1982; Fox and Smith, 1985) and pregnancy (Gallo et al., 1985) occurs in a pulsatile manner. Moreover, changes in the amplitude and frequency characteristics of this secretion take place with different stages of the 4-day estrous cycle and during different stages of gestation in this species. Plasma levels of estradiol (E2) and progesterone (P) also vary from stage to stage in the estrous cycle (Butcher et al., 1974; Kalra and Kalra, 1974b; Smith et al., 1975; Nequin et al., 1979) as well as during the different stages of pregnancy in the rat (Morishige et al., 1973; Taya and Greenwald, 1981; Bridges, 1984). The emphasis in our work is to study the neuroendocrine regulation of pulsatile LH secretion in a physiological context. Therefore, the aim of our experiments has been to first describe the normal changes that occur in LH pulse amplitude and frequency throughout the estrous cycle and pregnancy, and then to define the regulatory negative feedback roles of E2and/or P during each 24-h interval of the rat estrous cycle, and during specific stages of gestation.