Spermatogenic capacity in fertile men with elevated exposure to polychlorinated biphenyls.
Spermatogenic capacity in fertile men with elevated exposure to polychlorinated biphenyls.
复制标题
多氯联苯暴露量增加的育龄男性的生精能力。
DOI：
10.1016/j.envres.2015.02.030
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发表时间：
2015
影响因子：
8.3
通讯作者：
Jørgensen,N
中科院分区：
文献类型：
--
作者：
Petersen,MS;Halling,J;Weihe,P;Jensen,TK;Grandjean,P;Nielsen,F;Jørgensen,N
背景干扰内分泌的工业化学品，如多氯联苯（PCB），被怀疑对男性生殖功能产生不利影响。在这种情况下，我们研究了多氯联苯暴露和精液质量和生殖激素在生育法罗群岛男子之间的可能关联。在一项区域研究中，266名居住在法罗群岛的被证明有生育能力的男子被纳入研究。PCB水平和激素配置文件中采取的临床检查，其中包括精液质量parameters.ResultsA显着的正相关性之间的血清PCB和睾酮/雌二醇比值（p=0.04）的血清样本进行了测量。在未校正的分析中，PCB暴露量升高与SHBG（p=0.01）和FSH（p=0.05）血清浓度升高相关。我们没有发现血清PCB浓度和精液质量variables.ConclusionIn这个人口的高暴露生育力的男性，目前的血清PCB浓度与较高的雄激素/雌激素比例之间的关联。需要进一步的研究来确定这些发现，并进一步记录多氯联苯相关的激素效应、易感性增加的任何时间窗口以及多氯联苯在亚生殖力中的作用。
BackgroundEndocrine disrupting industrial chemicals, such as polychlorinated biphenyls (PCBs), are suspected to adversely affect male reproductive functions.ObjectivesThe Faroe Islands community exhibits an unusually wide range of exposures to dietary contaminants, and in this setting we examined the possible association between PCB exposure and semen quality and reproductive hormones in fertile Faroese men.MethodsParticipants in this cross-sectional study include 266 proven fertile men residing in the Faroe Islands. PCB levels and hormone profiles were measured in serum samples taken at the clinical examination that included semen quality parameters.ResultsA significant positive association was seen between serum-PCB and the testosterone/estradiol ratio (p=0.04). In the unadjusted analyses, elevated PCB exposure was associated with increased serum concentrations of SHBG (p=0.01) and FSH (p=0.05). We found no association between the serum PCB concentration and the semen quality variables.ConclusionIn this population of highly exposed fertile men, the current serum-PCB concentration was associated with higher androgen/estrogen ratio. Further studies are needed to establish the findings and further document PCB-associated hormonal effects, any time windows of increased susceptibility, and the role of PCB in sub-fecundity.