Brain MRI features of Chinese Han patients with MOG-antibody disease
Brain MRI features of Chinese Han patients with MOG-antibody disease
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DOI：
10.1016/j.msard.2020.102167
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发表时间：
2020-08-01
影响因子：
4
通讯作者：
Li, Yuxin
中科院分区：
文献类型：
--
作者：
Li, Haiqing;Yang, Liqin;Li, Yuxin
背景MOG抗体病（MOGAD）患者的影像学特征尚不清楚。我们旨在确定中国汉族队列中MOGAD的脑MRI特征，并评估MOGAD与视神经脊髓炎谱系障碍（NMOSDs）脑MRI特征的差异。方法回顾性分析43例MOGAD患者的MRI影像。作为常规诊断方法，所有患者均通过细胞法检测血清水通道蛋白4 IgG （AQP4-IgG）和MOG-IgG。脑病变的地形和特征由两名评分员独立评估。作为比较，我们还使用2015年国际NMO诊断小组（IPND）推荐的nmods的神经影像学特征来评估脑病变的地形和特征。结果35例（81.4%）患者出现脑损伤。这些脑损伤根据其分布可分为以下三种类型：(I)病变涉及中线结构和深灰色哑光；（II）幕上白质病变；（III）皮质灰质病变。17例脑病变不符合2015年IPND推荐的NMOSDs的神经影像学特征，其中11例为皮质灰质病变和/或皮质旁白质病变，4例为大脑中脚病变，2例为灰质病变和皮质旁白质病变，并伴有大脑中脚病变。结论中国汉族人群MOGAD表现出明显的脑MRI特征，特别是在皮层灰质病变、皮质旁白质病变和大脑中蒂病变方面，有助于在等待血清抗体结果时进一步识别和诊断MOGAD患者。
Background The spectrum of imaging features of patients with MOG antibody disease (MOGAD) remains unclear. We aimed to determine the brain MRI features of MOGAD in a Chinese Han cohort and to assess differences in brain MRI features between MOGAD and neuromyelitis optica spectrum disorders (NMOSDs).Methods We retrospectively reviewed the MRI images of 43 patients with MOGAD. As a routine diagnostic approach, all patients underwent serum aquaporin 4 IgG (AQP4-IgG) and MOG-IgG detection via cell-based assays. The topographies and features of brain lesions were independently assessed by two raters. As a comparison, topographies and features of brain lesions were also assessed using neuroimaging characteristics of NMOSDs recommended by the international panel for NMO diagnosis (IPND) in 2015.Results Thirty-five (81.4%) patients were found to have brain lesions. These brain lesions were classified into the following three patterns according to their distributions: (I) lesions involving midline structures and deep gray matte; (II) supratentorial white matter lesions; and (III) cortical gray matter lesions. There were 17 patients whose brain lesions did not fulfill the neuroimaging characteristics of NMOSDs recommended by the 2015 IPND, in which 11 patients had cortical gray matter lesions and/or juxtacortical white matter lesions, four patients had middle cerebral peduncles lesions, and two patients had gray matter lesions and juxtacortical white matter lesions, as well as middle cerebral peduncles lesions.Conclusion MOGAD in this Chinese Han cohort exhibited distinct brain MRI features, especially in terms of cortical gray matter lesions, juxtacortical white matter lesions, and middle cerebral peduncles lesions, which may help to further identify and diagnose patients with MOGAD while they are waiting for serological antibody results.