Time to retire the notion that local and whole-body exercise thresholds are mechanistically linked?
Time to retire the notion that local and whole-body exercise thresholds are mechanistically linked?
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是时候放弃局部运动阈值和全身运动阈值在机械上相关的观念了？
DOI：
10.1007/s00421-022-05082-3
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发表时间：
2023
影响因子：
3
通讯作者：
Koga S.
中科院分区：
文献类型：
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作者：
Goulding RP;Marwood S;Lei TH;Okushima D;Poole DC;Barstow TJ;Kondo N;Koga S.
然而，我们发现很难同意他们的主张，即“这些阈值与从大强度运动过渡到剧烈运动期间的生理事件共同相关”，并且“这些阈值是相关生理现象的表达”。这不仅基于作者自己的数据，还基于我们之前的研究，该研究表明呼吸代偿点（RCP）和肌肉脱氧断点（脱氧[血红素] BP）之间的关联可以通过实验分离（Goulding et al. 2021）。在此，我们提供 Caen 等人 (2022) 的另一种解释；结合我们最近的工作（Goulding et al. 2021），我们可以清楚地看出，局部代谢阈值并不以任何系统方式与系统阈值机械相关。对高强度运动阈值相关这一假设的一个关键检验是，在预期改变这两个参数的干预措施之后，任何这些阈值之间的一致性程度都应保持不变。在我们最近的论文中，我们使用直立与仰卧骑行来测试 RCP 和脱氧 [血红素] BP 之间的关系在预期影响肌肉 O2 输送的条件下是否保持稳定。此外，我们推断，如果 RCP 和脱氧 [血红素] BP 在机制上相关，那么无论在直立和仰卧条件下还是在直立和仰卧条件下，它们的关系在运动肌（即股外侧肌，VL；股直肌，RF）之间应该保持一致。我们发现，在 VL 直立位置（即最常测量这两个变量的条件）下，RCP 显着低于脱氧 [血红素] BP，这与目前（Caen 等人，2022 年，研究 2，表 4）和 Caen 等人（2018）之前的工作一致。我们还发现，Δ脱氧[血红素]BP与任一肌肉位置的ΔRCP均不相关，这一发现与Caen等人（2022）图2中呈现的这些变量之间的相关性不一致。此外，我们观察到 RCP 和脱氧 [血红素] BP 之间的一致性范围非常广泛（VL 中为 ±0.49，RF 中为 ±0.79 LO 2 min−1），这一发现与 Caen 等人 (2022) 指出的脱氧 [血红素] BP 较差的重测可靠性相一致。此外，尽管所有参与者都有单一的 RCP，但脱氧 [血红素] BP 发生在
However, we find it difficult to agree with their assertions that “these thresholds are collectively linked to the physiological events during the transition from heavy-to-severe intensity exercise”, and “these thresholds are expressions of linked physiological phenomena”. This is based not only on the authors’ own data but also on our previous study showing that the association between the respiratory compensation point (RCP) and muscle deoxygenation breakpoint (deoxy [heme] BP) can be experimentally dissociated (Goulding et al. 2021). Herein we offer an alternative interpretation of Caen et al.(2022); that, when considered alongside our recent work (Goulding et al. 2021), presents the clear perspective that local metabolic thresholds are not mechanistically linked to systemic thresholds in any systematic fashion.A crucial test of the hypothesis that high-intensity exercise thresholds are related is that the degree of agreement between any of these thresholds should remain following an intervention expected to alter both parameters. In our recent paper, we used upright versus supine cycling to test whether the relationship between RCP and deoxy [heme] BP would remain stable under conditions expected to impact muscle O2 delivery. Moreover, we reasoned that if the RCP and deoxy [heme] BP were mechanistically related, their relationship should remain consistent across locomotor muscles (ie, vastus lateralis, VL; rectus femoris, RF), both within and between upright and supine conditions. We found that RCP was significantly lower than deoxy [heme] BP in the upright position in the VL (ie, the conditions under which these two variables are most typically measured), which is consistent with the present (Caen et al. 2022, study 2, Table 4) and previous work of Caen et al.(2018). We also found that Δdeoxy [heme] BP did not correlate with ΔRCP across positions in either muscle, a finding which is inconsistent with the correlations between these variables presented in Fig. 2 by Caen et al.(2022). Moreover, we observed very wide limits of agreement between RCP and deoxy [heme] BP (±0.49 in the VL and±0.79 LO 2 min− 1 in the RF), a finding coherent with the poor test–retest reliability of the deoxy [heme] BP noted by Caen et al.(2022). Moreover, despite a singular RCP for all participants, the deoxy [heme] BP occurred at