BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery
BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery
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DOI：
10.1007/s11030-009-9157-5
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发表时间：
2010-02-01
影响因子：
3.8
通讯作者：
Titarenko, Zoya
中科院分区：
文献类型：
--
作者：
Kombarov, Roman;Altieri, Andrea;Titarenko, Zoya
已知药物（Comprehensive Medicinal Chemistry数据库（2008版）：http：//www.mdl.com/products/knowledge/medicinal_chem/index.jsp）和天然产物（Koch等人，Proc Natl Acad Sci USA 102：17272-17277，2008）导致了我们称为“BioCores”的特权饱和和芳族杂环对的鉴定。“这篇文章解释了BioCores如何用于新型铅样支架的设计。
The analysis of known drugs (Comprehensive Medicinal Chemistry database (2008 version): http://www.mdl.com/products/knowledge/medicinal_chem/index.jsp) and natural products (Koch et al., Proc Natl Acad Sci USA 102:17272-17277, 2008) has led to the identification of privileged saturated and aromatic heterocyclic ring pairs that we have termed as "BioCores." This article explains how the BioCores can be used for the design of novel lead-like scaffolds.