Redox control of growth factor signaling: recent advances in cardiovascular medicine.
Redox control of growth factor signaling: recent advances in cardiovascular medicine.
复制标题
生长因子信号传导的氧化还原控制：心血管医学的最新进展。
DOI：
10.1089/ars.2005.7.829
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发表时间：
2005
影响因子：
6.6
通讯作者：
Park,Ah-Mee
中科院分区：
文献类型：
--
作者：
Suzuki,YuichiroJ;Nagase,Hiroko;Nie,Kai;Park,Ah-Mee
生长因子在包括心血管和呼吸系统在内的各种生物过程的调节中起着至关重要的作用。越来越多的证据表明，活性氧参与了生长因子的信号转导。血管紧张素II通过激活NAD(P)H氧化酶在血管平滑肌细胞中产生活性氧物种的发现促进了对生长因子信号转导的氧化还原控制的研究。在过去的几年里，这一领域取得了进一步的进展。除了已证实的在血管平滑肌生长中的作用外，这些物种还被证明是血管紧张素II诱导的心肌肥大的第二信使。NAD(P)H氧化酶还在血管平滑肌和心肌细胞中产生响应内皮素-1的活性氧物种。这些结果表明，抑制NAD(P)H氧化酶可能是一种有用的治疗策略。事实上，腺病毒介导的基因转移似乎是预防啮齿动物模型血管肥大的有效方法。生长因子也可以在心肌和平滑肌细胞中诱导生存信号，氧化还原控制可能在这类事件中发挥作用。报道生长因子信号的氧化还原控制机制的研究很可能在接下来的几年里迅速出现，了解这种调节应该有助于开发治疗心肺疾病的策略。氧化还原信号。7,829-834。
Growth factors play vital roles in the regulation of various biologic processes, including those in cardiovascular and respiratory systems. Accumulating evidence suggests that reactive oxygen species mediate growth factor signal transduction. The discovery of reactive oxygen species production by angiotensin II in vascular smooth muscle cells via the activation of NAD(P)H oxidase promoted studies of redox control of growth factor signaling. In the past few years, there have been further advances in this field. In addition to established roles of reactive oxygen species in vascular smooth muscle growth, these species have been demonstrated to serve as second messengers for cardiac hypertrophy induced by angiotensin II. NAD(P)H oxidase also produces reactive oxygen species in response to endothelin-1 in vascular smooth muscle and cardiac muscle cells. These results suggest that inhibiting NAD(P)H oxidase might be a useful therapeutic strategy. In fact, adenovirusmediated gene transfer appears to be an effective approach to prevent vascular hypertrophy in rodent models. Growth factors also induce survival signaling in cardiac and smooth muscle cells, and redox control may play a role in such events. It is likely that studies reporting the mechanisms of redox control of growth factor signaling will rapidly emerge in the next several years, and understanding of such regulation should help in the development of therapeutic strategies against heart and lung diseases.Antioxid. Redox Signal.7, 829–834.