Different in vitro and in vivo behaviors between Poly(carboxybetaine methacrylate) and poly(sulfobetaine methacrylate)
Different in vitro and in vivo behaviors between Poly(carboxybetaine methacrylate) and poly(sulfobetaine methacrylate)
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聚（羧基甜菜碱甲基丙烯酸酯）和聚（磺基甜菜碱甲基丙烯酸酯）之间的不同体外和体内行为。
DOI：
10.1016/j.colsurfb.2016.07.016
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发表时间：
2016-10-01
影响因子：
5.8
通讯作者：
Chen, Shengfu
中科院分区：
文献类型：
--
作者：
Lin, Weifeng;Ma, Guanglong;Chen, Shengfu
聚(甲基丙烯酸磺基甜菜碱)(PSBMA)和聚(羧基甜菜碱甲基丙烯酸酯)(PCBMA)是两种著名的两性离子聚合物，它们具有优异的防污性能。在这项工作中，这两种两性离子聚合物在体外和体内进行了比较。这两种材料都表现出优异的防污性能和较低的巨噬细胞摄取率，尽管它们的水凝胶对非特异性蛋白的吸附和它们的星形聚合物的细胞内化的抵抗力可以忽略不计。然而，研究发现，β-环糊精-CBMA(CD-CBMA)的循环时间比CD-SBMA长一个数量级，这意味着体外的微小差异可能会导致体内的显著差异。这项工作表明，pCBMA在生物医学应用方面显示出比pSBMA更大的潜力。(C)2016爱思唯尔B.V.保留所有权利。
Poly(sulfobetaine methacrylate) (pSBMA) and poly(carboxybetaine methacrylate) (pCBMA) are two well-known zwitterionic polymers known for their excellent antifouling properties. In this work, these two zwitterionic polymers were compared both in vitro and in vivo. Both of them exhibited excellent antifouling properties and low macrophage uptake although there were negligible differences in resistance to nonspecific protein adsorption of their hydrogels and cell internalization of their star polymers. However, it is found that the beta- Cyclodextrin-CBMA (CD-CBMA) showed a circulation time one order of magnitude longer than CD-SBMA, which implied that small differences in vitro may lead to a dramatic difference in vivo. This work demonstrated that pCBMA showed greater potential than pSBMA in biomedical applications. (C) 2016 Elsevier B.V. All rights reserved.