Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis
Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis
复制标题
DOI：
10.1073/pnas.1320118110
复制
发表时间：
2013-12-03
影响因子：
11.1
通讯作者：
Nathan, Carl F.
中科院分区：
文献类型：
--
作者：
Rath, Poonam;Huang, Chengdong;Nathan, Carl F.
结核分枝杆菌 (Mtb) 能够很好地抑制免疫反应，从而避免被根除，但会引发足够的免疫病理学以确保其传播。在这里，我们提供的证据表明，这种宿主-病原体关系部分受到胞浆膜相关蛋白的调节，该蛋白具有独特的结构折叠，由 Mtb 基因 rv0431 编码。该蛋白通过调节带有 Toll 样受体 2 配体（包括脂蛋白 LpqH 和 SodC）的 Mtb 衍生膜囊泡的数量来发挥作用。我们建议将 rv0431 命名为“囊泡发生和免疫反应调节剂”。
Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator."