Interleukin-35 regulates the balance of Th17 and Treg responses during the pathogenesis of connective tissue diseases
Interleukin-35 regulates the balance of Th17 and Treg responses during the pathogenesis of connective tissue diseases
复制标题
Interleukin-35 在结缔组织疾病发病过程中调节 Th17 和 Treg 反应的平衡
DOI：
10.1111/1756-185x.13962
复制
发表时间：
2020
影响因子：
2.5
通讯作者：
Lei Ling
中科院分区：
文献类型：
--
作者：
Wang Di;Lei Ling
Interleukin (IL)‐35 belongs to the IL‐12 cytokine family and is a heterodimer of the p35 and Epstein‐Barr virus‐induced gene 3 (EBI3) subunits. Functionally, IL‐35 can promote the proliferation and activation of regulatory T cells (Tregs) and suppress the function of T helper 17 (Th17) cells and other inflammatory cells to inhibit immune responses. In recent years, an abnormal IL‐35 expression causing a Th17/Treg imbalance has been associated with the development and progression of several connective tissue diseases (CTDs), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis (DM)/polymyositis (PM), and primary Sjögren’s syndrome (pSS). Here, we review the role of IL‐35 in regulating the balance of Th17/Treg responses in different types of CTDs and provide new insights into the role of IL‐35 in these diseases.
