Interaction between APOE genotype and diabetes in cognitive decline
Interaction between APOE genotype and diabetes in cognitive decline
复制标题
APOE 基因型与糖尿病认知能力下降之间的相互作用
DOI：
10.1002/dad2.12006
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发表时间：
2020
影响因子：
5.3
通讯作者：
Sato Naoyuki
中科院分区：
文献类型：
--
作者：
Shinohara Mitsuru;Tashiro Yoshitaka;Suzuki Kaoru;Fukumori Akio;Bu Guojun;Sato Naoyuki
虽然糖尿病和载脂蛋白E(ApoE)都是包括阿尔茨海默病在内的痴呆的重要危险因素，但它们是如何导致痴呆风险的尚不清楚。方法通过回顾国家阿尔茨海默病协调中心(NACC)的临床记录，我们调查了糖尿病是否影响认知功能减退依赖于APOE基因及其与神经病理的潜在关系。结果糖尿病和APOE基因之间存在显著的交互作用，其中糖尿病影响APOE3和APOE2携带者的认知能力下降，而不是APOE4携带者。此外，糖尿病增加了ε3携带者血管病变的存在，而APOE4携带者几乎达到了平台期水平，无论患有何种糖尿病。讨论糖尿病加速认知能力下降，部分是通过加速非APOE APOE 4携带者的血管损害，但在APOE4携带者中，这种影响可以忽略不计，他们本身已经很容易受到血管损害的影响。
IntroductionAlthough diabetes and apolipoprotein E (apoE) are both significant risk factors for dementia, including Alzheimer's disease, it remains to be clarified how they are related to each other in contributing to the risk of dementia.MethodsBy reviewing the National Alzheimer's Coordinating Center (NACC) clinical records, we investigated whether diabetes affects cognitive decline depending onAPOEgenotype and their potential relationships with neuropathology.ResultsA significant interaction between diabetes andAPOEgenotype exists, where diabetes affected cognitive decline inAPOE3carriers andAPOE2carriers, but notAPOE4carriers. Moreover, the presence of vascular pathology was increased by diabetes inAPOE3carriers, whileAPOE4carriers nearly reached plateau levels irrespective of diabetes.DiscussionDiabetes accelerates cognitive decline, in part, through accelerating vascular impairment in non‐APOEε4 carriers, but such effects are negligible inAPOE4carriers, who themselves are already vulnerable to vascular impairment.