Phenotypic Changes in Diabetic Neuropathy Induced by a High-Fat Diet in Diabetic C57Bl/6 Mice
Phenotypic Changes in Diabetic Neuropathy Induced by a High-Fat Diet in Diabetic C57Bl/6 Mice
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DOI：
10.1155/2011/848307
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发表时间：
2011-01-01
影响因子：
--
通讯作者：
Wright, D. E.
中科院分区：
文献类型：
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作者：
Guilford, B. L.;Ryals, J. M.;Wright, D. E.
新出现的证据表明，血脂异常是糖尿病神经病变（DN）的独立风险因素（Vincent et al. 2009审查）。为了通过实验确定血脂异常是如何改变DN的，我们对高脂饮食喂养的糖尿病小鼠的神经病变症状进行了量化。链脲佐菌素诱导的糖尿病C57 BL/6小鼠喂食高脂饮食发展血脂异常和疼痛性神经病变（机械异常性疼痛），而不是无感觉神经病变（机械不敏感性），通常在这个应变。非糖尿病小鼠喂食高脂肪饮食也发展血脂异常和机械异常性疼痛。与非糖尿病小鼠相比，糖尿病小鼠的热敏感性显着降低，但高脂饮食并未使其恶化。此外，与非糖尿病小鼠相比，喂食高脂肪饮食的糖尿病小鼠的感觉和运动神经传导速度明显较慢。总之，高脂饮食引起的血脂异常可能改变DN表型和/或增加发生DN的风险。这些结果为血脂异常如何改变糖尿病神经病变的发展和表型提供了新的见解。
Emerging evidence suggests that dyslipidemia is an independent risk factor for diabetic neuropathy (DN) (reviewed by Vincent et al. 2009). To experimentally determine how dyslipidemia alters DN, we quantified neuropathic symptoms in diabetic mice fed a high-fat diet. Streptozotocin-induced diabetic C57BL/6 mice fed a high-fat diet developed dyslipidemia and a painful neuropathy (mechanical allodynia) instead of the insensate neuropathy (mechanical insensitivity) that normally develops in this strain. Nondiabetic mice fed a high-fat diet also developed dyslipidemia and mechanical allodynia. Thermal sensitivity was significantly reduced in diabetic compared to nondiabetic mice, but was not worsened by the high-fat diet. Moreover, diabetic mice fed a high-fat diet had significantly slower sensory and motor nerve conduction velocities compared to nondiabetic mice. Overall, dyslipidemia resulting from a high-fat diet may modify DN phenotypes and/or increase risk for developing DN. These results provide new insight as to how dyslipidemia may alter the development and phenotype of diabetic neuropathy.