The spectrum of MYH9-associated nephropathy.
The spectrum of MYH9-associated nephropathy.
复制标题
与MyH9相关的肾病的光谱。
DOI：
10.2215/cjn.08721209
复制
发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Freedman BI
中科院分区：
文献类型：
--
作者：
Bostrom MA;Freedman BI
非裔美国人慢性肾病发病率过高的原因长期以来一直在研究。最近，非肌肉肌球蛋白重链 9 基因 (MYH9) 的多态性与非洲和欧洲人群中的非糖尿病肾病相关。 MYH9 的风险变异导致非洲裔美国人中约 70% 的非糖尿病形式 ESRD 以及该种族群体中所有 ESRD 的 40% 至 45%，而对欧洲裔美国人的影响较小。很明显，MYH9 多态性对非裔美国人肾病的发病率有显着影响。本文介绍了目前经活检证实的 MYH9 相关肾脏疾病的范围，以及 MYH9 对临床结果种族差异的潜在影响。 MYH9 风险变异与迄今为止已发现的任何常见复杂肾脏疾病有着最令人印象深刻的关联。
Causes of the excess incidence rates of chronic kidney disease in the African American population have long been under study. Recently, polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) have been associated with nondiabetic kidney diseases in African- and European-derived populations. Risk variants in MYH9 contribute to approximately 70% of nondiabetic forms of ESRD in African Americans and 40 to 45% of all ESRD in this ethnic group, with lesser effects in European Americans. It is clear that MYH9 polymorphisms have a significant impact on the incidence rates of kidney disease in African Americans. This article describes the current spectrum of biopsy-proven MYH9-associated kidney diseases, along with potential effects of MYH9 on ethnic differences in clinical outcome. MYH9 risk variants exhibit the most impressive association with any common complex kidney disease yet identified.