Assessment of local pulse wave velocity in arteries using 2D distension waveforms
Assessment of local pulse wave velocity in arteries using 2D distension waveforms
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DOI：
10.1177/016173460102300401
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发表时间：
2001-10-01
影响因子：
2.3
通讯作者：
Hoeks, APG
中科院分区：
文献类型：
--
作者：
Meinders, JM;Kornet, L;Hoeks, APG
动脉脉搏波速度的倒数包含有关动脉壁机械特性的重要信息，但很难在体内进行无创评估。本文提出了一种评估局部脉搏波速度（PWV）的新方法。为此，使用具有高帧速率 (651 Hz) 的单个 2D 血管壁跟踪系统，沿短动脉段同时确定多个相邻的扩张波形。每个 B 模式图像由 16 条回波线组成，总宽度为 15.86 毫米。我们开发了专用软件，可以从 B 型图像中提取舒张末期直径，并从每条回波线的基础射频 (rf) 信息中提取扩张波形。 PWV是通过确定相邻扩张速度波形的时间和空间梯度的比率来获得的。所提出的方法在人体模型和人类颈总动脉（CCA）中得到了验证。模型实验显示，从 2D 扩张速度波形 (4.21 +/- 0.02 m/s) 获得的 PWV 与使用两个压力导管确定的 PWV (4.26 +/- 0.02 m/s) 之间具有高度一致性。假设线性空间梯度，也可以在体内获得 CCA 的 PWV，平均值为 5.5 +/- 1.5 m/s（受试者间差异，n = 23），这与文献中发现的值非常吻合。此外，受试者体内 PWV 与使用 Bramwell-Hill 方程计算的结果相比较。可以得出结论，如果空间梯度在观察到的动脉长度上是线性的，则可以从空间和时间梯度获得PWV，即动脉的直径和扩张应该是均匀的，并且反射的影响必须很小。
The reciprocal of the arterial pulse wave velocity contains crucial information about the mechanical characteristics of the arterial wall but is difficult to assess noninvasively in vivo. In this paper, a new method to assess local pulse wave velocity (PWV) is presented. To this end, multiple adjacent distension waveforms are determined simultaneously along a short arterial segment, using a single 2D-vessel wall tracking system with a high frame rate (651 Hz). Each B-mode image consists of 16 echo lines span ning a total width of 15.86mm. Dedicated software has been developed to extract the end-diastolic diameter from the B-mode image and the distension waveforms from the underlying radiofrequency (rf) information for each echo-line. The PWV is obtained by determining the ratio of the temporal and spatial gradient of adjacent distension velocity waveforms. The proposed method is verified in a Phantom and in the common carotid artery (CCA) of humans. Phantom experiments show a high concordance between the PWV obtained from 2D distension velocity waveforms (4.21 +/- 0.02 m/s) and the PWV determined using two pressure catheters (4.26 +/- 0.02 m/s). Assuming linear spatial gradients, the PWV can also be obtained in vivo for CCA and averages to 5.5 +/- 1.5 m/s (intersubject variation, n = 23), which compares well to values found in literature. Furthermore, intrasubject PWV compares well with those calculated using the Bramwell-Hill equation. It can be concluded that the PWV can be obtained from the spatial and temporal gradient if the spatial gradient is linear over the observed length of the artery, i.e. the artery should be homogenous in diameter and distension and the influence of reflections must be small.