Accelerated arteriosclerosis in heart transplant recipients is associated with a T-lymphocyte-mediated endothelialitis.
Accelerated arteriosclerosis in heart transplant recipients is associated with a T-lymphocyte-mediated endothelialitis.
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心脏移植受者的动脉硬化加速与 T 淋巴细胞介导的内皮炎有关。
DOI：
--
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发表时间：
1990
影响因子：
6
通讯作者：
G. Hutchins
中科院分区：
文献类型：
--
作者：
R. Hruban;W. Beschorner;William A. Baumgartner;Sharon M. Augustine;Hua Ren;Bruce A. Reitz;G. Hutchins
加速动脉硬化已成为心脏移植长期幸存者的一个主要危及生命的并发症。已经提出加速动脉硬化是免疫介导的排斥并发症。我们在两个移植心脏的冠状动脉中观察到显著的内皮细胞增生，这些心脏是从严重的移植相关的加速动脉硬化患者中获得的。这一发现促使我们回顾了23例接受心脏移植的尸检患者冠状动脉的病理变化。使用淋巴细胞（CD 45）、巨噬细胞（MAC-387）、T淋巴细胞（CD 45 RO）、B淋巴细胞（L-26）和平滑肌细胞（肌动蛋白）的免疫组织化学染色表征这些血管中的浸润。此外，一个完整的面板的单克隆抗体上使用的新鲜冷冻组织从两个心脏之一。11例加速动脉硬化的受者中有10例有中度至显著的淋巴细胞内皮炎，而14例无移植相关动脉硬化的受者中有3例有淋巴细胞内皮炎（P <0.005）。石蜡包埋材料的免疫组织化学染色表明，大多数的淋巴细胞在这些血管的内皮下空间的T淋巴细胞，这种浸润与巨噬细胞的积累和平滑肌细胞在内膜增殖。在新鲜冷冻组织可用于更详细细胞分型的心脏中，T细胞主要标记为细胞毒性T淋巴细胞（CD 8+，CD 2+）。这些结果表明，加速动脉硬化可能是介导的，在一定程度上，由细胞毒性T淋巴细胞定向内皮细胞。
Accelerated arteriosclerosis has emerged as a major life-threatening complication in long-term survivors of heart transplantation. It has been proposed that accelerated arteriosclerosis is an immune-mediated complication of rejection. We observed a striking endothelialitis in the coronary arteries of two explanted hearts obtained from patients with severe transplant-related accelerated arteriosclerosis. This finding prompted us to review the pathologic changes in the coronary arteries of 23 autopsied patients who had received heart transplants. The infiltrate in these vessels was characterized using immunohistochemical stains for lymphocytes (CD45), macrophages (MAC-387), T lymphocytes (CD45RO), B lymphocytes (L-26), and smooth muscle cells (actin). In addition, a full panel of monoclonal antibodies was used on the fresh-frozen tissue available from one of the two explanted hearts. Ten of the eleven recipients with accelerated arteriosclerosis had a moderate to marked lymphocytic endothelialitis compared to 3 of 14 without transplant-related arteriosclerosis (P less than 0.005). Immunohistochemical staining of the paraffin-embedded material demonstrated that most of the lymphocytes in the subendothelial space of these vessels were T lymphocytes and that this infiltrate was associated with an accumulation of macrophages and a proliferation of smooth muscle cells in the intima. In the explanted heart from which fresh-frozen tissue was available for more detailed cell typing, the T cells marked predominantly as cytotoxic T lymphocytes (CD8+, CD2+). These results suggest that accelerated arteriosclerosis may be mediated, in part, by a cytotoxic T-lymphocyte-directed endothelialitis.
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心脏移植受者严重加速冠状动脉疾病的再移植。
DOI：
10.1016/0002-9149(88)90885-5
发表时间：
1988
期刊：
The American journal of cardiology
影响因子：
--
作者：
Gao,SZ;Schroeder,JS;Hunt,S;Stinson,EB
通讯作者：
Stinson,EB
心脏移植中加速动脉粥样硬化：细胞毒性 B 细胞抗体和高脂血症的作用。
影响因子：
37.8
作者：
Hess,ML;Hastillo,A;Mohanakumar,T;Cowley,MJ;Vetrovac,G;Szentpetery,S;Wolfgang,TC;Lower,RR
通讯作者：
Lower,RR
影响因子：
0.9
作者：
Bieber,CP;Hunt,SA;Schwinn,DA;Jamieson,SA;Reitz,BA;Oyer,PE;Shumway,NE;Stinson,EB
通讯作者：
Stinson,EB
心脏移植动脉粥样硬化。
影响因子：
0.9
作者：
Billingham,ME
通讯作者：
Billingham,ME
影响因子：
4.6
作者：
S. Glagov;C. Zarins;D. Giddens;D. Ku
通讯作者：
S. Glagov;C. Zarins;D. Giddens;D. Ku