Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder
Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder
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DOI：
10.1097/00004583-199703000-00016
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发表时间：
1997-03-01
影响因子：
13.3
通讯作者：
Rapoport, JL
中科院分区：
文献类型：
--
作者：
Casey, BJ;Castellanos, FX;Rapoport, JL
目的：探讨注意缺陷多动障碍（ADHD）患者特殊的额纹状体结构（前额叶皮质和基底神经节）与反应抑制缺陷之间的关系。方法：ADHD儿童和年龄匹配的正常对照组使用磁共振成像（MRI）进行扫描，并进行三项反应抑制任务测试。行为表现与涉及ADHD的额纹状体回路（前额叶皮层和基底神经节）的MRI解剖测量相关。结果如下：首先，ADHD儿童和正常志愿者在所有三个反应抑制任务上的表现存在显着差异。其次，这些任务的表现只与ADHD儿童中观察到的异常额纹状体回路的解剖测量相关（例如，前额叶皮层、尾状核和苍白球区域，但不包括壳核）。第三，任务表现和解剖测量的前额叶皮层和尾状核之间的显着相关性主要是在右半球，支持右额纹状体电路的反应抑制和多动症的作用。结论：这些数据表明，右前额叶皮层的作用，在抑制反应显着，但其他无关的事件，而基底神经节似乎参与执行这些行为反应。
Objective: To examine the relation between specific frontostriatal structures (prefrontal cortex and basal ganglia) and response inhibition deficits observed in attention-deficit/hyperactivity disorder (ADHD). Method: Children with ADHD and age-matched normal controls were scanned using magnetic resonance imaging (MRI) and tested on three response inhibition tasks. Behavioral performance was correlated with MRI-based anatomical measures of frontostriatal circuitry (prefrontal cortex and basal ganglia) implicated in ADHD. Results: First, significant differences in performance by children with ADHD and normal volunteers were observed on all three response inhibition tasks. Second, performance on these tasks correlated only with those anatomical measures of frontostriatal circuitry observed to be abnormal in children with ADHD (e.g., the region of the prefrontal cortex, caudate, and globus pallidus, but not the putamen) in the authors' previous study. Third, significant correlations between task performance and anatomical measures of the prefrontal cortex and caudate nuclei were predominantly in the right hemisphere, supporting a role of right frontostriatal circuitry in response inhibition and ADHD. Conclusion: The data suggest a role of the right prefrontal cortex in suppressing responses to salient, but otherwise irrelevant events while the basal ganglia appear to be involved in executing these behavioral responses.