Decreased frontal cortical serotonin(2A) receptors in schizophrenia
Decreased frontal cortical serotonin(2A) receptors in schizophrenia
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DOI：
10.1016/0920-9964(96)00034-5
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发表时间：
1996-09-18
影响因子：
4.5
通讯作者：
Hayes, W
中科院分区：
文献类型：
--
作者：
Dean, B;Hayes, W
对精神分裂症患者和非精神分裂症患者的额叶皮质5 HT（2A）受体进行了测定。精神分裂症患者Brodmann氏8、9、10区5-HT（2A）受体密度降低。此外，在非精神分裂症患者的Brodmann第9区中，5 HT（2A）受体密度呈年龄依赖性降低，而精神分裂症患者则不存在这种现象。现有的证据并不表明精神分裂症受试者中5 HT（2A）受体的变化是死亡前药物治疗的结果。这些数据可能表明，额叶皮质中的5 HT（2A）受体减少参与精神分裂症的病理过程。
5HT(2A) receptors were measured in the frontal cortex from schizophrenic and non-schizophrenic subjects. There was a decrease in the density of 5HT(2A) receptors in Brodmann's areas 8, 9 and 10 from the schizophrenic subjects. In addition, there was an age-dependent decrease in the density of 5HT(2A) receptors in Brodmann's areas 9 from the non-schizophrenic subjects, which was absent in the schizophrenic subjects. Available evidence does not suggest that the change in 5HT(2A) receptors in the schizophrenic subjects was a result of drug treatment before death. These data may indicate that decreased 5HT(2A) receptors in the frontal cortex are involved in the pathology of schizophrenia.