ACID-LABILE HUMAN-LEUKOCYTE INTERFERON IN HOMOSEXUAL MEN WITH KAPOSIS SARCOMA AND LYMPHADENOPATHY
ACID-LABILE HUMAN-LEUKOCYTE INTERFERON IN HOMOSEXUAL MEN WITH KAPOSIS SARCOMA AND LYMPHADENOPATHY
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DOI：
10.1093/infdis/146.4.451
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发表时间：
1982-01-01
影响因子：
6.4
通讯作者：
VILCEK, J
中科院分区：
文献类型：
--
作者：
DESTEFANO, E;FRIEDMAN, RM;VILCEK, J
同性恋Kaposi S肉瘤(KS)或不明原因淋巴结病患者的某些免疫学指标与系统性红斑狼疮(SLE)等自身免疫性疾病患者相似。许多系统性红斑狼疮患者有一种不寻常的酸不稳定的人类白细胞干扰素(HuIFN-α)。在他们的血清中。对91名男同性恋者的血清进行了HuIFN的检测。27例KS患者中，17例血清中有明显滴度的Hu干扰素。35例淋巴结病患者中有10例，4例有其他临床症状的患者中有3例也有循环HuIFN。在25名看似健康的受试者中，只有2人有血清HuIFN。所有32个HuIFN样品都具有抗牛细胞病毒活性，这是HuIFN-α的特征，所测试的14个代表性样品都被HuIFN-α抗体中和。干扰素-α。在8名有代表性的患者中，有6名在pH值为2时失活，因此看起来类似于人干扰素-α。在系统性红斑狼疮患者中发现。因此，自身免疫性疾病可能会导致同性恋者的淋巴结病和KS。
Some immunologic parameters in homosexual patients with Kaposi''s sarcoma (KS) or unexplained lymphadenopathy resemble findings in patients with autoimmune diseases such as systemic lupus erythematosus (SLE). Many patients with SLE have an unusual acid-labile form of human leukocyte interferon (HuIFN-.alpha.) in their serum. Sera from 91 homosexual men were tested for the presence of HuIFN. Of 27 patients with KS, 17 had significant titers of HuIFN in their serum. Ten of 35 patients with lymphadenopathy and 3 of 4 patients with other clinical symptoms also had circulating HuIFN. Only 2 of 25 apparently healthy subjects had serum HuIFN. All 32 samples of HuIFN had antiviral activity on bovine cells, a characteristic of HuIFN-.alpha., and all of 14 representative samples tested were neutralized by antibody to HuIFN-.alpha.. The HuIFN-.alpha. in 6 of 8 representative patients was inactivated at pH 2 and therefore appears to be similar to the HuIFN-.alpha. found in patients with SLE. An autoimmune disorder may thus underly lymphadenopathy and KS in homosexual men.