A Rare Lung Nodule Consisting of Adenocarcinoma and Amyloid Deposition in a Patient with Primary Systemic AL Amyloidosis
A Rare Lung Nodule Consisting of Adenocarcinoma and Amyloid Deposition in a Patient with Primary Systemic AL Amyloidosis
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DOI：
10.2169/internalmedicine.50.4094
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发表时间：
2011-01-01
影响因子：
1.2
通讯作者：
Ikeda, Shu-ichi
中科院分区：
文献类型：
--
作者：
Miyazaki, Daigo;Yazaki, Masahide;Ikeda, Shu-ichi
一位60岁的妇女被发现有蛋白尿和肺结节。手术切除的左上叶包含一个结节，其中腺癌被淀粉样蛋白沉积包围。随后的肾脏和胃活检显示淀粉样蛋白沉积伴免疫反应性。经2个疗程VAD（长春新碱、阿霉素、地塞米松）治疗，Bence Jones蛋白尿消失。在随后的3年里，她的肾病综合征一直在改善。罕见的肺结节由腺癌和淀粉样蛋白沉积组成，是本例原发性全身性AL淀粉样变性患者的诊断线索。
A 60-year-old woman was found to have proteinuria and a lung nodule. The surgically resected left upper lobe contained a nodule, in which the adenocarcinoma was surrounded by a heavy deposition of amyloid. Subsequent renal and gastric biopsies demonstrated amyloid deposition with A. immunoreactivity. She was treated with 2 courses of VAD (vincristine, doxorubicin and dexamethasone), resulting in the disappearance of Bence Jones proteinuria. Her nephrotic syndrome has been improving during the subsequent 3 years. The rare lung nodule consisting of adenocarcinoma and amyloid deposition was a diagnostic clue in this primary systemic AL amyloidosis patient.