Functional evolution of the Myb oncogene family
Functional evolution of the Myb oncogene family
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DOI：
10.1006/bcmd.2001.0404
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发表时间：
2001-03-01
影响因子：
2.3
通讯作者：
Guthrie, E
中科院分区：
文献类型：
--
作者：
Lipsick, JS;Manak, J;Guthrie, E
迄今为止，在所有检查的脊椎动物中都发现了三个 Myb 相关基因（A-Myb、B-Myb 和 c-Myb），包括哺乳动物、鸟类和两栖动物。海胆和果蝇这两种无脊椎动物只有一种 Myb 相关基因。我们实验室以果蝇为模型系统，探索其唯一Myb基因的功能。我们还将三种不同的脊椎动物 Myb 基因重新引入果蝇中，以便开始了解它们的不同功能是如何在进化过程中基因复制后产生的。 (C) 2001 年学术出版社。
Three Myb-related genes (A-Myb, B-Myb, and c-Myb) have been found in all vertebrates examined thus far including mammals, birds, and amphibians. Two invertebrates, the sea urchin and the fruit fly, have only one Myb-related gene. Our laboratory has used Drosophila as a model system to explore the function of its sole Myb gene. We have also reintroduced the three different vertebrate Myb genes into Drosophila in order to begin to understand how their different functions may have arisen following gene duplication during evolution. (C) 2001 Academic Press.