MDM2 309 polymorphism is associated with missed abortion.
MDM2 309 polymorphism is associated with missed abortion.
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DOI：
10.1093/humrep/dep044
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发表时间：
2009-06
影响因子：
6.1
通讯作者：
Yan Fang;B. Kong;Qifeng Yang;D. Ma;X. Qu
中科院分区：
文献类型：
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作者：
Yan Fang;B. Kong;Qifeng Yang;D. Ma;X. Qu
在这项研究中，我们评估了小鼠双微体2（MDM 2）启动子（SNP 309）的单核苷酸多态性是否与稽留流产的发生相关。方法采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术，对95例早期稽留流产妇女的血液和绒毛组织进行MDM 2基因SNP 309多态性分型。结果MDM 2SNP 309 G/G基因型与稽留流产的危险性显著高于T/T+ T/G基因型（P = 0.010;比值比（OR）：2.164; 95%可信区间（CI）：1.207-3.878）和绒毛样本（P = 0.043; OR：2.767; 95% CI：1.092-7.011）。结论MDM 2SNP 309 G/G基因型可能是稽留流产的遗传危险因素。
BACKGROUND In this study, we assessed whether the single nucleotide polymorphism in the murine double minute 2 (MDM2) promoter (SNP309) was associated with the occurrence of missed abortion. METHODS Genotyping of MDM2 SNP309 polymorphism was conducted by polymerase chain reaction-restriction fragment length polymorphism with blood and villous samples from 95 women diagnosed as having 1st trimester missed abortion. RESULTS The MDM2 SNP309 G/G genotype was associated with a higher risk of missed abortion compared with the T/T+ T/G genotype in blood (P = 0.010; odds ratio (OR): 2.164; 95% confidence interval (CI): 1.207-3.878) and villous samples (P = 0.043; OR: 2.767; 95% CI: 1.092-7.011). CONCLUSIONS The MDM2 SNP309 G/G genotype may be a genetic risk factor for missed abortion.