ANTICOCCIDIAL ACTIVITY OF SALINOMYCIN IN BATTERY RAISED BROILER-CHICKENS
ANTICOCCIDIAL ACTIVITY OF SALINOMYCIN IN BATTERY RAISED BROILER-CHICKENS
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DOI：
10.3382/ps.0560926
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发表时间：
1977-01-01
期刊：
影响因子：
4.4
通讯作者：
MILLER, RL
中科院分区：
文献类型：
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作者：
DANFORTH, HD;RUFF, MD;MILLER, RL
用单种艾美耳球虫、米瓦蒂艾美耳球虫、极大艾美耳球虫、柔嫩艾美耳球虫、坏死艾美耳球虫和布鲁内蒂艾美耳球虫，以及混合感染6种艾美耳球虫，进行了3种不同剂量的盐霉素(AHR-3096)的抗球虫试验，盐霉素是一株白色链霉菌的发酵产物。在60-100ppm的处理水平下，该化合物对所研究的所有参数(死亡率、增重、饲料转化率、下降分数和病变分数)都显示出显著的抗球虫活性。用药感染鸡球虫病死亡率降至0.1%。以体重增加衡量的一些活性在较低水平的盐霉素药物(12.5-50ppm)中被看到，但包括死亡率和病变评分在内的其他参数表明，与较高水平的治疗相比，活性较低。在100ppm时，该化合物对未受感染的对照禽类的生产性能没有明显影响。在控制球虫病方面，100ppm的盐霉素在统计学上与121ppm的莫能菌素(参考抗球虫药)一样有效。
Infections with single species of Eimeria acervulina, E. mivati, E. maxima, E. tenella, E. necatrix and E. brunetti, and the 6 species mixed, were utilized in 3 separate battery experiments to evaluate the anticoccidial efficacy of various levels of salinomycin (AHR-3096), a fermentation product of a strain of Streptomyces albus. At the 60-100 ppm treatment levels, this compound showed significant anticoccidial activity for all parameters studied (mortality, weight gain, feed conversion, dropping scores and lesion scores). The mortality due to coccidiosis was reduced to 0.1% in the medicated infected birds. Some activity, as measured by weight gain, was seen in the lower levels of salinomycin medication (12.5-50 ppm) but other parameters, including mortality and lesion scores, indicated less activity than that seen with the higher treatment levels. At 100 ppm, there was no apparent effect of the compound on bird performance in unifected control birds. Salinomycin at the 100 ppm treatment level was statistically as effective as 121 ppm monensin (reference anticoccidial) in controlling coccidiosis.