Obesity and its relationship with asthma prevalence and severity in adolescents from southern Brazil
Obesity and its relationship with asthma prevalence and severity in adolescents from southern Brazil
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DOI：
10.1080/02770900500448597
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发表时间：
2006-01-01
影响因子：
1.9
通讯作者：
Menna-Barreto, SS
中科院分区：
文献类型：
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作者：
Cassol, VE;Rizzato, TM;Menna-Barreto, SS
肥胖已被指出是青少年哮喘和哮喘相关症状患病率较高的危险因素。目的是应用国际儿童哮喘和过敏症研究(ISAC)方案，评估居住在圣玛丽亚及其周围环境(巴西南部南里奥格兰德州)的青少年中哮喘和肥胖的患病率之间的关系。共有6,123名13至14岁的学龄儿童中的4,010人参加了Isaac III阶段方案(哮喘核心问卷)，并进行了营养评估：身高、体重和三头肌皮褶(TSF)测量。根据肥胖和非肥胖的营养状况，评估和比较哮喘(最近12个月内有喘息)和重度哮喘(有4次以上哮喘急性发作、言语障碍、睡眠障碍、运动喘息)的发生率。肥胖青少年的定义为：体重指数(BMI，单位为kg/m(2))=第85个百分位数，TSF=第85个百分位数。肥胖组和非肥胖组的哮喘患病率和哮喘严重程度的比较使用卡方检验和95%可信区间的优势比(OR)。对所有青少年进行分析，我们观察到肥胖的患病率与“有喘息”(OR=1.28；95%CI为1.08-1.52)、“运动时有喘息(OR=1.36；95%CI为1.11-1.66)”、“有哮喘(OR=1.29；95%CI为1.03-1.62)”和重度哮喘(OR=1.55；95%CI为1.12-2.14)呈显著正相关。在男孩中，肥胖与“喘息”呈显著正相关(OR=1.49；95%CI为1.13~1.86)。在女孩中，“曾经哮喘(OR=1.38；95%CI为1.01~1.88)”和“运动中喘息(OR=1.36；95%CI为1.11~1.66)”呈显著正相关。这项对居住在巴西南部地区的青少年进行的横断面研究表明，肥胖与哮喘症状的患病率和哮喘严重程度之间存在正相关，这一发现主要限于女孩。
Obesity has been pointed out as a risk factor for higher prevalence of asthma and asthma-related symptoms in adolescents. The objective was to evaluate the relationship between the prevalence of asthma and obesity in adolescents living in Santa Maria and surroundings (state of Rio Grande do Sul, southern Brazil), applying the International Study of Asthma and Allergies in Childhood (ISAAC) protocol. A total of 4,010 of 6,123 schoolchildren, 13 to 14 years of age, enrolled in the ISAAC phase III protocol (asthma core questionnaire) and were nutritionally evaluated: height, weight, and triceps skinfold (TSF) measurements. Prevalence of asthma (wheeze in the last 12 months) and prevalence of severe asthma (two or more affirmative responses to: more than 4 acute attacks of asthma, speech disturbance, sleep disturbance, wheezing with exercise) were evaluated and compared according to their nutritional status: obese and non-obese. Obese adolescents were defined by body mass index (BMI, in kg/m(2)) =85th percentile and TSF =85th percentile. Obese and non-obese groups were compared for prevalence of asthma and asthma severity using the Chi-square test and odds ratio (OR) with 95% confidence interval. Analyzing all adolescents, we observed a significant positive relationship between the prevalence of obesity and affirmative responses to "wheeze ever (OR = 1.28; 95% CI 1.08-1.52), "wheezing with exercise (OR = 1.36; 95% CI 1.11-1.66), "asthma ever (OR = 1.29; 95% CI 1.03-1.62), and severe asthma (OR = 1.55; 95% CI 1.12-2.14). Among the boys, there was a significant positive association between obesity and "wheeze ever (OR = 1.49; 95% CI 1.13-1.86). In girls, there was a significant positive relationship with "asthma ever (OR = 1.38; 95% CI 1.01-1.88) and "wheezing with exercise (OR = 1.36; 95% CI 1.11-1.66). This cross-sectional study with adolescents living in the southern region of Brazil showed that there is a positive association between obesity and prevalence of asthma symptoms and asthma severity, a finding mainly confined to girls.